163914-14-5

Basic information

• Product Name: 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene
• Synonyms: 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene
• CAS NO: 163914-14-5
• Molecular Weight: 293.001
• Mol File: 163914-14-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene(163914-14-5)
• EPA Substance Registry System: 1-bromo-2-(bromomethyl)-4-(dimethylamino)benzene(163914-14-5)

Safety Data

• Hazardous Substances Data: 163914-14-5(Hazardous Substances Data)

Upstream product

• 163913-92-6 5-(N,N-dimethylamino)-2-bromobenzyl alcohol 
• 23501-93-1 3-dimethylaminobenzyl alcohol 
• 99-64-9 3-(dimethylamino)benzoic acid 
• 16518-64-2 3-(dimethylamino)benzoic acid methyl ester 
• 164513-41-1 methyl 2-bromo-5-(N,N-dimethylamino)benzoate 

Downstream Products

• 163913-96-0 2-(2-Bromo-5-dimethylamino-benzyl)-3-{(2S,3S,4R,5S)-5-[(2S,3S)-3-((1R,2S)-1-methyl-2-trimethylsilanyloxy-propyl)-oxiranylmethyl]-3,4-bis-trimethylsilanyloxy-tetrahydro-pyran-2-ylmethyl}-but-3-enoic acid methoxy-methyl-amide 

Relevant articles and documents

Antiangiogenic versus cytotoxic activity in analogues of aeroplysinin-1

A series of analogues of the potentially angiogenic inhibitor aeroplysinin-1 1 were synthesized and their in vitro antiangiogenic and cytotoxic activities evaluated. In the case of epoxy ketone 6 and azlactone 36 the relationship sprouting inhibition assay/cytotoxicity in BAE cells was enhanced by one order and two orders of magnitude, respectively, with respect to the reference. These results imply more specific antiangiogenic properties for the synthesized derivatives.

Preparation of E-(2-substituted-1-methylethylidene)indanones derived from monic acid

Alkylation of the lithium dienolate of the monic acid hydroxamate (3) with o-bromo(bromomethyl) benzene or heteroaromatic derivatives gave α-alkylated products (5). This alkylation procedure was surprisingly catalysed by 4- dimethylaminopyridine. Metal-halogen exchange with t-butyl lithium occurred with concomitant intramolecular cyclisation to give a mixture of the deconjugated ketones (6). Reconjugation with potassium t-butoxide stereoselectively produced the E-isomer (7). Deprotection gave the monic acid derived ketone (1).