163913-92-6Relevant articles and documents
An efficient synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide
Wang, Chaolei,Wu, Zheng,Wang, Jia,Liu, Jie,Yao, Hequan,Lin, Aijun,Xu, Jinyi
, p. 8172 - 8177 (2015/12/30)
The synthesis of 4-isochromanones via Parham-type cyclization with Weinreb amide as the internal electrophilic group, t-BuLi as the lithium reagent was described. The reaction was efficient and could be completed in one minute. The application scope of this new protocol was investigated and the desired products could be obtained in good to excellent yields. Besides, the synthetic potential of this method was further demonstrated by the synthesis of natural product (±)-XJP, which was obtained in six steps with overall yield up to 54%.
2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF
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Page/Page column 84, (2009/10/22)
The present invention discloses fused bicyclic 2-aryl- or 2-heteroarylthiazolyl compounds and their pharmaceutically acceptable salts and esters thereof, which are useful for inhibiting the growth of cancerous cells, inhibiting human breast carcinoma tumo
Preparation of E-(2-substituted-1-methylethylidene)indanones derived from monic acid
Pearson, Neil D.,Broom, Nigel J.P.,O'Hanlon, Peter J.
, p. 3771 - 3774 (2007/10/02)
Alkylation of the lithium dienolate of the monic acid hydroxamate (3) with o-bromo(bromomethyl) benzene or heteroaromatic derivatives gave α-alkylated products (5). This alkylation procedure was surprisingly catalysed by 4- dimethylaminopyridine. Metal-halogen exchange with t-butyl lithium occurred with concomitant intramolecular cyclisation to give a mixture of the deconjugated ketones (6). Reconjugation with potassium t-butoxide stereoselectively produced the E-isomer (7). Deprotection gave the monic acid derived ketone (1).
