163958-99-4Relevant academic research and scientific papers
Enzyme-mediated enantioselective hydrolysis of cyclic carbonates
Matsumoto, Kazutsugu,Fuwa, Seiji,Kitajima, Hidehiko
, p. 6499 - 6502 (1995)
The enzyme-mediated enantioselective hydrolysis of cyclic carbonates is disclosed. Racemic 4-(2-benzyloxy)ethyl-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-benzyloxybutane-1,2-diol (2a). PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enantioselectivity.
