Tetrahedron Letters p. 6499 - 6502 (1995)
Update date:2022-08-04
Topics: Enantioselective Hydrolysis Cyclic carbonates Enzyme-Mediated
Matsumoto, Kazutsugu
Fuwa, Seiji
Kitajima, Hidehiko
The enzyme-mediated enantioselective hydrolysis of cyclic carbonates is disclosed. Racemic 4-(2-benzyloxy)ethyl-1,3-dioxolan-2-one (1a) was enantioselectively hydrolyzed by porcine pancreas lipase (PPL) to give optically active (R)-1a and (S)-4-benzyloxybutane-1,2-diol (2a). PPL also catalyzed the hydrolysis of several five-membered cyclic carbonates with high enantioselectivity.
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