163959-89-5Relevant academic research and scientific papers
Highly enantio- and diastereoselective boron aldol reactions of α-heterosubstituted thioacetates with aldehydes and silyl imines
Gennari, Cesare,Vulpetti, Anna,Pain, Gilles
, p. 5909 - 5924 (1997)
Boron enolates derived from α-heterosubstituted thioacetates and bearing menthone-derived chiral ligands react with aldehydes to give anti aldols with excellent diastero- and enantiocontrol. Boron enolates derived from tert-butyl α-halothioacetate and bearing menthone-derived chiral ligands react with imines with excellent diastero- and enantiocontrol to give syn α-halo-β-aminothioesters, which can be converted to the corresponding aziridines by simple ring closure during LAH reduction. A key precursor of antibiotics (+)-thiamphenicol and (-)-florfenicol was synthesized.
A Highly Enantio- and Diastereoselective Aldol Reaction for α-Heterosubstituted Thioacetates
Gennari, Cesare,Vulpetti, Anna,Moresca, Daniela
, p. 4857 - 4860 (2007/10/02)
Boron enolates derived from α-heterosubstituted thioacetates and bearing menthonederived chiral ligands reacts with aldehydes to give anti aldols with excellent diastereo- and enantiocontrol.
