16396-31-9Relevant academic research and scientific papers
Potential Anticancer Benzo-naphthyridones with Fused Rings: a Theoretical Model for Predicting Orientation in the Cyclization of Intermediates
Mefetah, Hafid,Brouant, Pierre,Galy, Anne-Marie,Galy, Jean-Pierre,Barbe, Jacques
, p. 522 - 533 (2007/10/03)
Synthesis of benzo[b]-1,8-naphthyridine-5-ones with fused ring from halonicotinic acids and amino-substituted benzoheterocycles, leads either to an isomeric mixture or to single isomers. MO calculations conducted on the starting amino-substituted benzoheterocycles, allow predictions of the derivative(s) to be obtained. Some selected compounds belonging to this series were screened in vitro against several human tumor cell lines.
