163979-83-7

Basic information

• Product Name: 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine
• Synonyms: 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine
• CAS NO: 163979-83-7
• Molecular Weight: 264.37
• Mol File: 163979-83-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine(163979-83-7)
• EPA Substance Registry System: 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine(163979-83-7)

Safety Data

• Hazardous Substances Data: 163979-83-7(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 6345-94-4 N-(4-chlorobutyl)benzamide 
• 3389-54-6 n-benzoylpyrrolidine 
• 163979-85-9 N-(4-p-tolylamino-butyl)-benzamide 

Relevant articles and documents

1H-4,5,6,7-tetrahydro-1,3-diazepines. Part I: Synthesis, spectral and chemical properties of 1,2-diaryl derivatives

The synthesis of several 1,2-diaryl-1H-4,5,6,7-tetrahydro-1,3-diazepines 1 by cyclization of N-aryl-N′-benzoyltetramethylenediamines 2 is described. Two alternative synthetic routes to obtain precursors 2 are discussed, being that which employes pyrrolidine as starting material the most convenient. Nucleophilic attack of compounds 1 on methyl iodide affords 1,2-diaryl-1H-4,5,6,7-tetrahydro-1,3-diazepinium iodides 3. 1H-nmr spectra of these compounds are unequivocally assigned by means of NOESY experiments. 1H-nmr spectra of compounds 1 and 3 are analyzed and compared inter se and with those of compounds 1 run in the presence of trifluoroacetic acid-d. Reduction of compounds 1 with borane leads regiospecifically to N-aralkyl-N′-aryltetramethylenediamines 7.