6345-94-4

Upstream product

• 31991-78-3 uvariadiamide 
• 10026-13-8 phosphorus pentachloride 
• 3389-54-6 n-benzoylpyrrolidine 
• 98-88-4 benzoyl chloride 
• 2782-40-3 N-butylbenzamide 
• 102877-79-2 N-(4-hydroxybutyl)benzamide 

Downstream Products

• 104560-52-3 1,4-bis-(4-benzoylamino-butyl)-piperazine 
• 93406-12-3 N-benzoyl-4-phenylbutylamine 
• 5692-23-9 N-(4-aminobutyl)benzamide 
• 163979-82-6 1,2-diphenyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine 
• 163979-83-7 2-phenyl-1-p-tolyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine 
• 163979-93-9 1-(4-chloro-phenyl)-2-phenyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine 
• 163979-92-8 1-(4-methoxy-phenyl)-2-phenyl-4,5,6,7-tetrahydro-1H-[1,3]diazepine 
• 1245641-03-5 N-benzoyl-N'-(3,4-dichlorophenyl)tetramethylenediamine 
• 163979-91-7 N-[4-(4-chloro-phenylamino)-butyl]-benzamide 
• 163979-85-9 N-(4-p-tolylamino-butyl)-benzamide 
• 857488-39-2 4-benzamidobutyl iodide 
• 163979-84-8 N-(4-phenylamino-butyl)-benzamide 

Relevant academic research and scientific papers

Photoinduced C(sp3)-H chlorination of amides with tetrabutyl ammonium chloride

A new protocol was developed for the site-selective C(sp3)-H chlorination of amides with tetrabutyl ammonium chloride as the chlorinating agent. The reaction features a tandem sequence that involves a (diacetoxyiodo)benzene-mediated and chloride anion-involved N-H chlorination followed by photoinitiated chlorine atom transfer. A wide variety of carboxamides and sulfonamides were chlorinated at the δ-position by using this method.

Photoinduced site-selective C(sp3)-H chlorination of aliphatic amides

Herein, we report a new photochemical method for C(sp3)-H chlorination of amides which employs tert-butyl hypochlorite as the chlorinating agent and a household compact fluorescent lamp as the light source. The reaction proceeds via N-heterocyclic carbene SIPr·HCl-promoted N-H chlorination and subsequent photoinduced Hofmann-L?ffler-Freytag chlorine atom transfer. The latter process is facilitated by (diacetoxyiodo)benzene. This protocol exhibits a broad scope and is suitable for site-selective chlorination of methyl hydrogen as well as methylene and methine hydrogen.

DECONSTRUCTIVE FUNCTIONALIZATION METHODS AND COMPOUNDS

Disclosed herein, inter alia, are deconstructive functionalization methods and compounds made using the same.

Halogenation of primary alcohols using a tetraethylammonium halide/[Et 2NSF2]BF4 combination

The halogenation of primary alcohols is presented. The use of a combination of tetraethylammonium halide and [Et2NSF2]BF4 (XtalFluor-E) allows for chlorination and bromination reactions to proceed efficiently (up to 92% yield) with a wide range of alcohols. Iodination reactions are also possible albeit in lower yields.