163981-35-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 163981-34-8 (R)-(+)-methyl 3-hydroxy-2-(3-methoxyphenyl)-2-methylpropionate 
• 163981-33-7 (R)-(+)-2-(methoxycarbonyl)-2-(3-methoxyphenyl)propionic acid 

Downstream Products

• 163981-36-0 (S)-(+)-3-(tert-butyldimethylsiloxy)-2-(3-methoxyphenyl)-2-methyl-1-propanol 
• 163981-38-2 (R)-(-)-ethyl 5-(tert-butyldimethylsilyloxy)-4-(3-methoxyphenyl)-4-methylent-2-enoate 
• 163981-39-3 (R)-(+)-4-(3-methoxyphenyl)-4-methyl-5-pentanolide 
• 163981-37-1 (R)-(-)-3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropanal 

Relevant academic research and scientific papers

Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of natural (-)aphanorphine

Enantiomerically pure (+)-dihydronaphthalene 4, a precursor of (-)-aphanorphine, was obtained from the homochiral malonic acid ester (R)-(+)-5, via the chiral lactone (+)-12 prepared by a Wittig-Horner reaction and hydrogenation, which underwent subsequent acidic Friede-Crafts cyclisation.