(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

Base Information

Chemical Name:(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate
CAS No.:163981-35-9
Molecular Formula:C₁₈H₃₀O₄Si
Molecular Weight:338.519
Hs Code.:

Synonyms:(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

Chemical Property:

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Technology Process of (R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

There total 4 articles about (R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 163981-34-8
(R)-(+)-methyl 3-hydroxy-2-(3-methoxyphenyl)-2-methylpropionate

: 163981-35-9
(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(95)00097-9

Reference yield:

: 163981-33-7
(R)-(+)-2-(methoxycarbonyl)-2-(3-methoxyphenyl)propionic acid

: 163981-35-9
(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Et₃N / 1.) THF, -15 deg C, 15 min, 2.) THF, -15 deg C, 15 min

2: NaBH₄ / tetrahydrofuran; methanol / 1 h / 0 °C

3: 92 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(95)00097-9

Reference yield:

: dimethyl 2-methyl-2-(3-methoxyphenyl)malonate

: 163981-35-9
(R)-(+)-methyl 3-(tert-butyldimethylsilyloxy)-2-(3-methoxyphenyl)-2-methylpropionate

Guidance literature:: Multi-step reaction with 4 steps

1: aq. NaOH / 60 h / 25 °C / pig liver esterase (PLE)

2: 1.) Et₃N / 1.) THF, -15 deg C, 15 min, 2.) THF, -15 deg C, 15 min

3: NaBH₄ / tetrahydrofuran; methanol / 1 h / 0 °C

4: 92 percent / imidazole / dimethylformamide

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/0957-4166(95)00097-9