16401-80-2

Basic information

• Product Name: Delmetacin
• Synonyms: Delmetacin;1-benzoyl-2-methyl-1H-indole-3-acetic acid
• CAS NO: 16401-80-2
• Molecular Formula: C₁₈H₁₅NO₃
• Molecular Weight: 293.32
• Mol File: 16401-80-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 433.2°Cat760mmHg
• Flash Point: 215.8°C
• Appearance: /
• Density: 1.22g/cm³
• Vapor Pressure: 2.84E-08mmHg at 25°C
• Refractive Index: 1.623
• CAS DataBase Reference: Delmetacin(CAS DataBase Reference)
• NIST Chemistry Reference: Delmetacin(16401-80-2)
• EPA Substance Registry System: Delmetacin(16401-80-2)

Safety Data

• Hazardous Substances Data: 16401-80-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H15NO3/c1-12-15(11-17(20)21)14-9-5-6-10-16(14)19(12)18(22)13-7-3-2-4-8-13/h2-10H,11H2,1H3,(H,20,21)

Upstream product

• 1912-43-2 2-methyl-3-indoleacetic acid 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. In particular, 2(ortho)-substituted arylacetic acids or their derivatives, such as amides and sulfonamides, lack cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.