1640122-69-5Relevant articles and documents
Triflic Acid as an Efficient Br?nsted Acid Promoter for the Umpolung of N-Ac Indoles in Hydroarylation Reactions
Nandi, Raj Kumar,Perez-Luna, Alejandro,Gori, Didier,Beaud, Rodolphe,Guillot, Régis,Kouklovsky, Cyrille,Gandon, Vincent,Vincent, Guillaume
, p. 161 - 172 (2017/11/23)
We report that triflic acid, a strong Br?nsted acid, is a very powerful alternative to FeCl3 to mediate the hydroarylation of N?Ac indoles, which delivers regioselectively 3-arylindolines, 3,3-spiroindolines or 2-arylindolines. Mechanistic explorations point towards the existence of a highly electrophilic intermediate by simultaneous activation of the acetyl and of the C2=C3 bond by protons. (Figure presented.).