1640122-86-6

Basic information

• Product Name: 3-(N-acetyl-5-bromo-3-methylindolin-3-yl)-1-tosylindole
• Synonyms: 3-(N-acetyl-5-bromo-3-methylindolin-3-yl)-1-tosylindole
• CAS NO: 1640122-86-6
• Molecular Weight: 523.45
• Mol File: 1640122-86-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(N-acetyl-5-bromo-3-methylindolin-3-yl)-1-tosylindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(N-acetyl-5-bromo-3-methylindolin-3-yl)-1-tosylindole(1640122-86-6)
• EPA Substance Registry System: 3-(N-acetyl-5-bromo-3-methylindolin-3-yl)-1-tosylindole(1640122-86-6)

Safety Data

• Hazardous Substances Data: 1640122-86-6(Hazardous Substances Data)

Upstream product

• 31271-90-6 1-(p-toluenesulfonyl)-1H-indole 
• 1152163-74-0 1-(5-bromo-3-methyl-1H-indol-1-yl)ethanone 
• 92557-51-2 5-Bromo-indole-3-carbinol 
• 10075-48-6 5-bromo-3-methyl-1H-indole 
• 877-03-2 5-bromo-1H-indole-3-carboxaldehyde 

Relevant articles and documents

Regioselective hydroarylation reactions of C3 electrophilic N-acetylindoles activated by FeCl3: An entry to 3-(Hetero)arylindolines

A method for the direct and rare umpolung of the 3 position of indoles is reported. The activation of N-acetylindole with iron(III) chloride allows the C-H addition of aromatic and heteroaromatic substrates to the C2-C3 double bond of the indole nucleus to generate a quaternary center at C3 and leads regioselectively to 3-arylindolines. Optimization, scope (50 examples), practicability (gram scale, air atmosphere, room temperature), and mechanistic insights of this process are presented. Synthetic transformations of the indoline products into drug-like compounds are also described.