164020-75-1Relevant academic research and scientific papers
Chiral Induction in Aryl Radical Cyclization to the Aldimino Functional Group
Tomaszewski, Miroslaw J.,Warkentin, John
, p. 966 - 968 (1993)
6-endo Cyclization of aryl radicals to carbon of aldimino double bonds (N-5/C-6) in chiral ortho-substituents afforded 1,2,3,4-tetrahydroisoquinolines in yields to 69percent, with 58percent d.e. and 97percent e.e., while 5-exo cyclization to carbon in isomeric radicals (C-5/N-6 aldimine), leading to indanamines, was highly regioselective and fast, k5-exo = 3.9 * 108 s-1 at 80 deg C.
