164033-11-8

Basic information

• Product Name: (R)-1-PHENYLPROPYL ISOCYANATE
• Synonyms: (R)-1-PHENYLPROPYL ISOCYANATE
• CAS NO: 164033-11-8
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 164033-11-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 195-197°C 7mm
• Flash Point: 195-197°C/7mm
• Appearance: /
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: (R)-1-PHENYLPROPYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-PHENYLPROPYL ISOCYANATE(164033-11-8)
• EPA Substance Registry System: (R)-1-PHENYLPROPYL ISOCYANATE(164033-11-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38-52-22
• Safety Statements: 23-26-36/37/39
• RIDADR: 2206
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 164033-11-8(Hazardous Substances Data)

Usage

General Description

(R)-1-Phenylpropyl isocyanate is a chemical compound with the molecular formula C10H11NO, consisting of a phenyl group attached to a propyl chain that is linked to an isocyanate functional group. (R)-1-PHENYLPROPYL ISOCYANATE is primarily used in the production of polyurethane, a versatile synthetic polymer with wide-ranging applications in industries such as construction, automotive, and furniture manufacturing. (R)-1-Phenylpropyl isocyanate is a key component in the formation of polyurethane foam, coatings, adhesives, and elastomers. It is known for its ability to enhance the strength, durability, and performance of polyurethane materials, making it an essential building block in the production of various high-quality industrial and consumer products. However, it is important to handle (R)-1-Phenylpropyl isocyanate with caution, as it is a hazardous material that can cause skin and respiratory irritation if proper safety measures are not followed.

Upstream product

• 75-44-5 phosgene 
• 2941-20-0 1-phenylpropylamine 
• 938-79-4 (2R)-2-phenylbutanoic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 

Downstream Products

• 2941-20-0 1-phenylpropylamine 
• 223266-59-9 4(S)-Benzyl-3(S)-(methylthio)-2-oxoazetidine-1-carboxylic acid (1(R)-phenylpropyl)amide 
• 256410-63-6 4-[(2S,3S)-3-(2-Ethoxy-benzyl)-4-oxo-1-((R)-1-phenyl-propylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-41-0 4-[(2S,3S)-3-(2-Methoxy-benzyl)-4-oxo-1-((R)-1-phenyl-propylcarbamoyl)-azetidin-2-yloxy]-benzoic acid 
• 256410-64-7 4-[(2S,3S)-3-(2-Ethoxy-benzyl)-4-oxo-1-((R)-1-phenyl-propylcarbamoyl)-azetidin-2-yloxy]-benzoic acid benzhydryl ester 
• 256410-42-1 (3S,4S)-4-(4-diphenylmethoxycarbonyl)phenoxy-3-(2-methoxybenzyl)-1-[(R)-(1-phenylpropyl)aminocarbonyl]azetidin-2-one 
• 1027517-70-9 4-[(2S,3S)-3-Ethyl-4-oxo-1-((R)-1-phenyl-propylcarbamoyl)-3-propyl-azetidin-2-yloxy]-benzoic acid tert-butyl ester 
• 856000-41-4 (3R,4S)-4-<<4-<(1,1-dimethylethoxy)carbonyl>phenyl>oxy>-3-ethyl-3-methyl-1-<<<(R)-1-(1-phenylpropyl)>amino>carbonyl>azetidin-2-one 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

The present invention provides compounds that inhibit Factor XIa or kallikrein and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of using these compounds and compositions.

A modified Curtius reaction: an efficient and simple method for direct isolation of free amine

The Curtius rearrangement and related reactions are often used to convert carboxylic acids to the corresponding primary amines. However, this reaction often requires harsh conditions for hydrolysis of the isocyanate intermediates to amines, and can also be contaminated by the formation of corresponding ureas due to the reactive nature of the intermediates. We have discovered that by quenching the isocyanate intermediates with sodium trimethylsilanolate, the free amines can be isolated after aqueous workup. This mild and fast procedure provides free amines in one pot with good yields.

Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors

3-Benzylazetidine-2-one derivatives were designed and evaluated as a novel series of chymase inhibitors. Structure-activity relationship studies of 3-benzylazetidine-2-ones led to compounds 23, which exhibited 3.1nM inhibition of human chymase and enhancement of stability in human plasma (t1/2 6 h). Copyright