164033-12-9

Basic information

• Product Name: (S)-(-)-1-PHENYLPROPYL ISOCYANATE
• Synonyms: (S)-(-)-1-PHENYLPROPYL ISOCYANATE
• CAS NO: 164033-12-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2
• Mol File: 164033-12-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 195-196°C 7mm
• Flash Point: 195-196°C/7mm
• Appearance: /
• Density: 0.97±0.1 g/cm3(Predicted)
• Refractive Index: 1.5145
• Sensitive: Moisture Sensitive
• BRN: 6799586
• CAS DataBase Reference: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(164033-12-9)
• EPA Substance Registry System: (S)-(-)-1-PHENYLPROPYL ISOCYANATE(164033-12-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38-42-52-22
• Safety Statements: 23-26-36/37/39-45
• RIDADR: 2206
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 164033-12-9(Hazardous Substances Data)

Usage

General Description

(S)-(-)-1-PHENYLPROPYL ISOCYANATE is a chemical compound that belongs to the class of isocyanates, which are known for their reactivity and widespread use in various industries. It is specifically an isocyanate with a phenylpropyl group attached to the nitrogen atom. This chemical is commonly used as a building block in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals, due to its ability to react with a wide range of nucleophiles. However, it is important to handle (S)-(-)-1-PHENYLPROPYL ISOCYANATE with caution, as it is known to be irritant to the skin, eyes, and respiratory system, and can cause sensitization upon repeated exposure. Therefore, proper safety measures and handling procedures should be followed when working with this compound.

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 3789-59-1 (R)-1-phenylpropylamine 
• 75-44-5 phosgene 

Downstream Products

• 1110641-90-1 (R)-6-allyl-3-((S)-1-(4-bromophenyl)propyl)-6-phenyl-1,3-oxazinan-2-one 
• 1161825-74-6 (S)-3-(1-phenylpropyl)-8-carbamoylimidazo[5,1-d][1,2,3,5]tetrazin-4-one 

Relevant articles and documents

SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Disclosed are syntheses of 11 beta-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticold effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).