16408-40-5Relevant academic research and scientific papers
Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d] imidazoles and imidazo[4,5-f] [1,10]phenanthrolines
Patel, Alpa,Sharp, Swee Y.,Hall, Katelan,Lewis, William,Stevens, Malcolm F.G.,Workman, Paul,Moody, Christopher J.
, p. 3889 - 3905 (2016)
The imidazole ring is widespread in biologically active compounds, and hence imidazole-containing scaffolds are useful starting points for drug discovery programmes. We report the synthesis of a series of novel imidazole-containing compounds fused with either phenanthrene or phenanthroline, which show enhanced growth inhibitory potency against human colon, breast and melanoma cancer cell lines, as well as evidence of inhibition of the molecular chaperone heat shock protein 70 (Hsp70) pathway in cells, as shown by depletion of downstream oncogenic client proteins of the Hsp90 chaperone pathway, and induction of apoptosis.
Silver-mediated Cα(sp3)-H functionalization of primary amines: An oxidative C-N coupling strategy for the synthesis of two different types of 1,2,4,5-tetrasubstituted imidazoles
Sarkar, Rajib,Mukhopadhyay, Chhanda
, p. 1246 - 1256 (2015/03/04)
A new silver(I)-mediated Cα(sp3)-H bond functionalization of primary amines and subsequent oxidative C-N cross-coupling reaction has been demonstrated. This protocol provides a simple, highly efficient, and straightforward approach to form significantly diverse 1,2,4,5-tetrasubstituted imidazoles. In this course of the reaction, a stoichiometric amount of Ag2CO3 was employed. Upon completion of reaction, the silver species was successfully recycled and reused without any loss of activity. Good to excellent yields of the products were readily achieved by using this selective oxidative C-N coupling, which was promoted by a crucial silver(I) salt.
Ni(ii)-salt catalyzed activation of primary amine-sp3C α-H and cyclization with 1,2-diketone to tetrasubstituted imidazoles
Samanta, Srikanta,Roy, Dipanwita,Khamarui, Saikat,Maiti, Dilip K.
supporting information, p. 2477 - 2480 (2014/03/21)
NiCl2·6H2O and Ni(OAc)2· 4H2O were found as efficient catalysts for C-H activation of benzyl and aliphatic amines for an unprecedented multi C-N bond forming cyclization with 1,2-diketones under refluxing toluene to furnish highly substituted and polycyclic imidazoles.
