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164083-07-2

1H-Indole-3-acetamide, 2-bromo-5-hydroxy-1-(phenylmethyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 164083-07-2 Structure

  • Basic information

    1. Product Name: 1H-Indole-3-acetamide, 2-bromo-5-hydroxy-1-(phenylmethyl)-
    2. Synonyms:
    3. CAS NO:164083-07-2
    4. Molecular Formula: C17H15BrN2O2
    5. Molecular Weight: 359.222
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 164083-07-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Indole-3-acetamide, 2-bromo-5-hydroxy-1-(phenylmethyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Indole-3-acetamide, 2-bromo-5-hydroxy-1-(phenylmethyl)-(164083-07-2)
    11. EPA Substance Registry System: 1H-Indole-3-acetamide, 2-bromo-5-hydroxy-1-(phenylmethyl)-(164083-07-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 164083-07-2(Hazardous Substances Data)

164083-07-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 164083-07-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,0,8 and 3 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 164083-07:
(8*1)+(7*6)+(6*4)+(5*0)+(4*8)+(3*3)+(2*0)+(1*7)=122
122 % 10 = 2
So 164083-07-2 is a valid CAS Registry Number.

164083-07-2Relevant articles and documents

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 2. Indole-3-acetamides with additional functionality

Dillard, Robert D.,Bach, Nicholas J.,Draheim, Susan E.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre

, p. 5137 - 5158 (1996)

As reported in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed. The design of these compounds was based on information derived from x-ray crystal structures determined for complexes between the enzyme and its inhibitors. We describe here the further implementation of this structure-based design strategy and continued SAR development to produce indole-3-acetamides with additional functionalities which provide increased interaction with important residues within the enzyme active site. These efforts led to inhibitors with substantially enhanced potency and selectivity.

1H-INDOLE-3-ACETAMIDE SPLA2 INHIBITORS

-

, (2008/06/13)

A class of novel 1-indole-3-acetamides represented by the formula; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids.

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