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164083-06-1

1H-Indole-3-acetamide, 2-bromo-5-methoxy-1-(phenylmethyl)- is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 164083-06-1 Structure

  • Basic information

    1. Product Name: 1H-Indole-3-acetamide, 2-bromo-5-methoxy-1-(phenylmethyl)-
    2. Synonyms:
    3. CAS NO:164083-06-1
    4. Molecular Formula: C18H17BrN2O2
    5. Molecular Weight: 373.249
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 164083-06-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1H-Indole-3-acetamide, 2-bromo-5-methoxy-1-(phenylmethyl)-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1H-Indole-3-acetamide, 2-bromo-5-methoxy-1-(phenylmethyl)-(164083-06-1)
    11. EPA Substance Registry System: 1H-Indole-3-acetamide, 2-bromo-5-methoxy-1-(phenylmethyl)-(164083-06-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 164083-06-1(Hazardous Substances Data)

164083-06-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 164083-06-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,0,8 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 164083-06:
(8*1)+(7*6)+(6*4)+(5*0)+(4*8)+(3*3)+(2*0)+(1*6)=121
121 % 10 = 1
So 164083-06-1 is a valid CAS Registry Number.

164083-06-1Relevant articles and documents

1H-INDOLE-3-ACETAMIDE SPLA2 INHIBITORS

-

, (2008/06/13)

A class of novel 1-indole-3-acetamides represented by the formula; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Dillard, Robert D.,Bach, Nicholas J.,Draheim, Susan E.,Berry, Dennis R.,Carlson, Donald G.,Chirgadze, Nickolay Y.,Clawson, David K.,Hartley, Lawrence W.,Johnson, Lea M.,Jones, Noel D.,McKinney, Emma R.,Mihelich, Edward D.,Olkowski, Jennifer L.,Schevitz, Richard W.,Smith, Amy C.,Snyder, David W.,Sommers, Cynthia D.,Wery, Jean-Pierre

, p. 5119 - 5136 (2007/10/03)

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.

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