164083-26-5

Basic information

• Product Name: Carbamic acid, [3-methoxy-2-(2-oxopropyl)phenyl]-, 1,1-dimethylethyl ester
• CAS NO: 164083-26-5
• Molecular Formula: C15H21NO4
• Molecular Weight: 279.336
• Mol File: 164083-26-5.mol

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [3-methoxy-2-(2-oxopropyl)phenyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [3-methoxy-2-(2-oxopropyl)phenyl]-, 1,1-dimethylethyl ester(164083-26-5)
• EPA Substance Registry System: Carbamic acid, [3-methoxy-2-(2-oxopropyl)phenyl]-, 1,1-dimethylethyl ester(164083-26-5)

Safety Data

• Hazardous Substances Data: 164083-26-5(Hazardous Substances Data)

Upstream product

• 78191-00-1 N-Methoxy-N-methylacetamide 
• 164082-77-3 tert-butyl (3-methoxy-2-methylphenyl)carbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 598-30-1 sec.-butyllithium 
• 172733-39-0 formyl N-methoxy-N-methylformamide 
• 19500-02-8 2-methyl-3-methoxyaniline 

Downstream Products

• 17897-50-6 4-methoxy-2-methylindole 
• 164083-29-8 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide 
• 164083-28-7 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid ethyl ester 
• 185063-74-5 [1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide 
• 185063-93-8 [1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetic acid ethyl ester 
• 164083-56-1 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetic acid hydrazide 
• 164083-55-0 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester 
• 164084-54-2 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetamide 
• 185063-78-9 2-[1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetamide 
• 164083-57-2 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetamide 

Relevant articles and documents

AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

sPLA2 inhibitor ester

The compound, ((3(2-amino-1,2-dioxoethyl)-2-methyl-1-(phenylmethyl)-1H-indol-4-yl)oxy)acetic acid N-morpholino ester, is disclosed together with its use as a highly bioavailable indole sPLA2inhibitor compound.

1H-INDOLE-3-GLYOXYLAMIDE SPLA2 INHIBITORS

A class of novel 1H-indole-3-glyoxylamides is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty adds for treatment of conditions such as septic shock

1H-INDOLE-3-ACETAMIDE SPLA2 INHIBITORS

A class of novel 1-indole-3-acetamides represented by the formula; is disclosed together with the use of such indole compounds for inhibiting sPLA2 mediated release of fatty acids.

Indole inhibitors of human nonpancreatic secretory phospholipase A2. 1. Indole-3-acetamides

Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been detected in several pathological conditions. An inhibitor of this enzyme could have therapeutic utility. A broad screening program was carried out to identify chemical structures which could inhibit hnps-PLA2. One of the lead compounds generated by the screening program was 5-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid (13a). We describe the syntheses, structure-activity relationships, and pharmacological activities of a series of indole-3-acetamides and related compounds derived from this lead. This SAR was undertaken with the aid of X- ray crystal structures of complexes between the inhibitors and hnps-PLA2 which were of great value in directing the SAR.