17897-50-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Methoxy-2-methyl-1H-indole is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs targeting specific biological pathways.
Used in Biochemical Research:
In the field of biochemical research, 4-methoxy-2-methyl-1H-indole serves as a valuable tool for studying the structure-activity relationship (SAR) of inhibitors targeting human nonpancreatic secretory phospholipase A2. This enzyme plays a crucial role in various physiological processes, and its inhibition can have therapeutic implications for treating inflammation and other related conditions.
Used in Chemical Synthesis:
4-Methoxy-2-methyl-1H-indole can be utilized as a starting material or building block in the synthesis of more complex organic molecules, such as natural products, pharmaceuticals, and other specialty chemicals. Its reactivity and functional groups make it a versatile compound for chemical modifications and transformations.

Upstream product

• 153865-35-1 (3-Chloro-4-methoxy-phenyl)-isopropylidene-amine 
• 19500-02-8 2-methyl-3-methoxyaniline 
• 5345-54-0 3-chloro-4-methoxyaniline 
• 50868-74-1 acetic acid-(3-methoxy-2-methyl-anilide) 
• 146564-00-3 1‐(benzenesulfonyl)‐4‐methoxy‐1H‐indole 
• 1093759-59-1 4-methoxyindole-1-carboxylic acid tert-butyl ester 
• 4837-90-5 4-methoxy-1H-indole 
• 39232-91-2 m-methoxyphenylhydrazine hydrochloride 
• 164082-77-3 tert-butyl (3-methoxy-2-methylphenyl)carbamate 
• 164083-26-5 1-(2-(tert-butoxycarbonylamino)-6-methoxyphenyl)-2-propanone 

Downstream Products

• 185298-21-9 4-Methoxy-2-methyl-1-(2-methyl-benzyl)-1H-indole 
• 172732-99-9 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole 
• 1026657-11-3 1-(2-Chloro-benzyl)-4-methoxy-2-methyl-1H-indole 
• 164083-29-8 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid hydrazide 
• 164083-28-7 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetic acid ethyl ester 
• 185063-74-5 [1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetic acid hydrazide 
• 185063-93-8 [1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetic acid ethyl ester 
• 164083-56-1 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetic acid hydrazide 
• 164083-55-0 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester 
• 164084-54-2 4-methoxy-2-methyl-1-(phenylmethyl)-1H-indole-3-acetamide 
• 185063-78-9 2-[1-(3-Chloro-benzyl)-4-methoxy-2-methyl-1H-indol-3-yl]-acetamide 
• 164083-57-2 1-([1,1'-biphenyl]-2-ylmethyl)-4-methoxy-2-methyl-1H-indole-3-acetamide 
• 172732-78-4 4-hydroxy-2-methyl-1-(phenylmethyl)-1H-indole 
• 172733-00-5 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole 

Relevant academic research and scientific papers

Cu-Catalyzed Oxidation of C2 and C3 Alkyl-Substituted Indole via Acyl Nitroso Reagents

The selective oxidation of C2-alkyl-substituted indoles to 3-oxindole and the selective C-H oxygenation or amination of C2,C3-dialkyl-substituted indoles at C2 are reported under mild conditions. The position of the alkyl substitution on the indole directs the reaction to different pathways under similar conditions.

Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity

Certain indolyl-pyridinyl-propenone analogues kill glioblastoma cells that have become resistant to conventional therapeutic drugs. Some of these analogues induce a novel form of non-apoptotic cell death called methuosis, while others primarily cause micr

Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

The AAA-ATPase p97 plays vital roles in mechanisms of protein homeostasis, including ubiquitin-proteasome system (UPS) mediated protein degradation, endoplasmic reticulum-associated degradation (ERAD), and autophagy. Herein we describe our lead optimization efforts focused on in vitro potency, ADME, and pharmaceutical properties that led to the discovery of a potent, ATP-competitive, D2-selective, and orally bioavailable p97 inhibitor 71, CB-5083. Treatment of tumor cells with 71 leads to significant accumulation of markers associated with inhibition of UPS and ERAD functions, which induces irresolvable proteotoxic stress and cell death. In tumor bearing mice, oral administration of 71 causes rapid accumulation of markers of the unfolded protein response (UPR) and subsequently induces apoptosis leading to sustained antitumor activity in in vivo xenograft models of both solid and hematological tumors. 71 has been taken into phase 1 clinical trials in patients with multiple myeloma and solid tumors.

PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS

The present invention relates to a compound of the formula (I), or a pharmaceutically acceptable salt thereof, wherein R1-R8 and X, m, and n are defined. Compounds and compositions of the present invention are useful the treatment of atherosclerosis.

AZAINDOLE COMPOUNDS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

INDOLE COMPOUNDS HAVING C4-AMIDE SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

INDOLE COMPOUNDS HAVING C4-ACIDIC SUBSTITUENTS AND USE THEREOF AS PHOSPHOLIPASE-A2 INHIBITORS

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

PHOSPHOLIPASE INHIBITORS, INCLUDING MULTI-VALENT PHOSPHOLIPASE INHIBITORS, AND USE THEREOF, INCLUDING AS LUMEN-LOCALIZED PHOSPHOLIPASE INHIBITORS

The present invention provides methods and compositions for the treatment of phospholipase-related conditions. In particular, the invention provides a method of treating insulin-related, weight-related conditions and/or cholesterol-related conditions in an animal subject. The method generally involves the administration of a non-absorbed and/or effluxed phospholipase A2 inhibitor that is localized in a gastrointestinal lumen.

Multivalent indole compounds and use thereof as phospholipase-A2 inhibitors

Indole and indole-related compounds, compositions and methods are disclosed. The compounds of the invention are useful as phospholipase inhibitors. The compounds and compositions of the invention are useful for treatment of phospholipase-related conditions, such as insulin-related, weight-related and/or cholesterol-related conditions in an animal subject.

NOVEL HETEROARYL DERIVATIVE

A compound of the following formula (1), or its prodrug or pharmaceutically acceptable salt thereof, being useful as a diabetic medicine or preventive, or blood sugar regulator, or therapeutic agent for hyperlipemia, etc. wherein the ring Z is an optionally substituted heteroaryl, W4 is a single bond, lower alkylene, etc., Ar2 is an optionally substituted aryl, etc., W3 is a single bond, lower alkylene, etc., Ar1 is an optionally substituted arylene, etc., each of W1 and W2 is an optionally substituted lower alkylene, etc., and R1 is carboxyl, an alkoxycarbonyl.