1641-12-9

Usage

Appearance

Yellow crystalline powder The compound is a yellow-colored solid that forms crystals.

Molecular weight

322.34 g/mol The molecular weight of the compound is 322.34 grams per mole.

Derivative of 1H-indene-1,3(2H)-dione

The compound is derived from 1H-indene-1,3(2H)-dione, which is a structural basis for the chemical.

Methoxy groups

Two methoxy groups attached to the phenyl ring and two methoxy groups attached to the indene ring The compound contains a total of four methoxy groups (-OCH3) that are attached to the phenyl and indene rings, which influence its chemical properties.

Usage in organic synthesis and chemical research

The compound is utilized in organic synthesis processes and chemical research for various purposes.

Potential biological and pharmacological activities

The compound has been studied for its possible biological and pharmacological activities, which could be beneficial in various applications.

Potential applications in drug and pharmaceutical development

Due to its unique chemical structure and properties, 2-(3,4-dimethoxyphenyl)-4,5-dimethoxy-1H-indene-1,3(2H)-dione may contribute to the development of new drugs and pharmaceuticals.

Upstream product

• 86633-30-9 3,4,3',4'-tetramethoxydeoxybenzoin ethylene acetal 
• 4927-55-3 1,2-bis(3,4-dimethoxyphenyl)ethanone 
• 91-16-7 1,2-dimethoxybenzene 
• 86633-38-7 3-(3,4-dimethoxybenzylidene)-6,7-dimethoxyphthalide 

Relevant academic research and scientific papers

Influence of Alkoxyalkyl Substituents in the Regioselective Lithiation of the Benzene Ring

The concomitant presence of an alkoxyalkyl group (α-alkoxyalkyl, α- or β-dialkoxyalkyl) and of an alkoxy group in the relative positions 1 and 3 in a benzene ring generally permits an easy lithiation of position 2 by proton-metal exchange with n-butyllithium; the only aromatic compound tested, bearing a β-alkoxyalkyl group, gave, however, extensive decomposition in the metalation step.Reaction of the metalated species with an electrophile (such as carbon dioxide or ethyl chloroformate) leads to the corresponding substituted products in good to excellent yields.The following transformations are described: 3,4-dimethoxybenzyl α-ethoxyethyl ether (1) into 6,7-dimethoxyphthalide (15); 3,4-(methylenedioxy)benzyl α-ethoxyethyl ether (2) into 6,7-(methylenedioxy)phthalide (16); 3,4-dimethoxybenzyl methyl ether (3) into ethyl 2-(methoxymethyl)-5,6-dimethoxybenzoate (18) and into ethyl 2-(chloromethyl)-5,6-dimethoxybenzoate (20); 3,4-(methylenedioxy)benzyl methyl ether (4) into ethyl 2-(methoxymethyl)-5,6-(methylenedioxy)benzoate (19) and into ethyl 2-(chloromethyl)-5,6-(methylenedioxy)benzoate (21); 3,4-dimethoxybenzaldehyde dimethyl acetal (5) into 5,6-dimethoxyphthalaldehydic acid (22); 3,4-(methylenedioxy)benzaldehyde dimethyl acetal (6) into 5,6-(methylenedioxy)phthalaldehydic acid (23); (3,4-dimethoxyphenyl)acetaldehyde dimethyl acetal (7) into ethyl 2-(2,2-dimethoxyethyl)-5,6-dimethoxybenzoate (25); 3,4,4'-trimethoxydeoxybenzoin ethylene acetal (10) into 2-(ethoxycarbonyl)-3,4,4'-trimethoxydeoxybenzoin (26); 4,3',4'-trimethoxydeoxybenzoin ethylene acetal (11) into 2'-(ethoxycarbonyl)-4,3',4'-trimethoxydeoxybenzoin (27); 3,4,3',4'-tetramethoxydeoxybenzoin ethylene acetal (12) into a mixture of 3-(3,4-dimethoxybenzylidene)-6,7-dimethoxyphthalide (28) and 3-(3,4-dimethoxyphenyl)-7,8-dimethoxyisocoumarin (29).The dioxole ring of methylenedioxy-substituted benzenes is sometimes unstable under these metalation conditions, and partial decomposition usually causes the yields to be lower than those in the case of the corresponding methoxy-substituted benzenes.Many of the products listed above, which have been already prepared by other methods, are more conveniently obtained by the present approach.