1641-17-4 Usage
Originator
Uvistat-L,Ward Blenkinsop,UK,1960
Uses
Different sources of media describe the Uses of 1641-17-4 differently. You can refer to the following data:
1. sunscreen
2. 2-Hydroxy-4-methoxy-4'-methyl-benzophenone is an UV absorbing agent in sunscreen cosmetic creams, lotions, lipstieks, sun oils, etc.
Preparation
Preparation by Friedel–Crafts acylation of m-methoxy-phenol with p-toluoyl chloride,in the presence of boron trichloride in benzene first at ?10°, then at reflux for 10 h under nitrogen (80%)in the presence of titanium tetrachloride in benzene first at ?10°, then at reflux for 14 h under nitrogen (73%) or in chlorobenzene for 1 h at 120° (79%).
Manufacturing Process
p-Toluoyl chloride is the starting material. To this is added chlorobenzene and
1,3-dimethoxybenzene. The reaction mixture is cooled to 12°C in an ice bath
and aluminum chloride is added gradually, keeping the reaction below 30°C.
The reaction is then gradually heated to 115°C with the evolution of hydrogen
chloride gas. As the temperature increases, the reaction mixture becomes
thicker. At 105°C, dimethyl formamide is added slowly. The reaction is heated
at 115°C for a short time and is then poured into concentrated hydrochloric acid. The reaction mixture pours very easily and very cleanly. The acid
mixture is heated with steam to dissolve all the material which had not
hydrolyzed and the mixture is filtered. The red chlorobenzene layer is
separated and washed twice with hot water.To the chlorobenzene solution is then added sodium hydroxide dissolved in
water and the chlorobenzene is removed by a steam distillation. After all of
the chlorobenzene is removed, the precipitate which forms during the
distillation is removed by filtration and discarded. The solution is cooled and
acidified with hydrochloric acid, precipitating a tan solid. This is removed by
filtration and washed acid-free. It is then treated with sodium bicarbonate
solution to remove any acid present and is then washed with water to remove
all traces of bicarbonate. After drying approximately a 75% yield of mexenone
is obtained.
Therapeutic Function
Sunscreen agent
Contact allergens
BZP-10 is exceptionally positive in ketoprofen-photosensitive
patients.
Check Digit Verification of cas no
The CAS Registry Mumber 1641-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,4 and 1 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1641-17:
(6*1)+(5*6)+(4*4)+(3*1)+(2*1)+(1*7)=64
64 % 10 = 4
So 1641-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O3/c1-10-3-5-11(6-4-10)15(17)13-8-7-12(18-2)9-14(13)16/h3-9,16H,1-2H3
1641-17-4Relevant articles and documents
Eco-friendly organocatalyst- And reagent-controlled selective construction of diverse and multifunctionalized 2-hydroxybenzophenone frameworks for potent UV-A/B filters by cascade benzannulation
Akhtar, Muhammad Saeed,Inductivo Tamargo, Ramuel John,Kim, Sung Hong,Lee, Yong Rok,Thombal, Raju S.,Yang, Won-Guen
supporting information, p. 4523 - 4531 (2020/08/10)
The organocatalyst- and reagent-controlled highly selective synthesis of diversely functionalized novel 2-hydroxybenzophenone frameworks, such as 2-hydroxy-3′-formylbenzophenones, 7-(2′-hydroxybenzoyl)-2-naphthaldehydes, and 2-hydroxybenzophenones, under green conditions, for the development of potent UV-A/B filters is described. The organocatalyzed benzannulation reactions proceed individually via [3 + 3] cycloaddition for the synthesis of 2-hydroxy-3′-formylbenzophenones and [4 + 2] cycloaddition for 2-hydroxybenzophenones. With this methodology, an unprecedented double benzannulation allows one-pot construction of diverse 7-(2′-hydroxybenzoyl)-2-naphthaldehydes via [3 + 3 + 4] cycloaddition. This protocol features a broad substrate scope, high functional-group tolerance, and operational simplicity in an environmentally benign green solvent. The synthesized compounds are successfully utilized for further transformations and well characterized as potent UV-A/B filters.
Synthesis of 2-acylphenol and flavene derivatives from the ruthenium-catalyzed oxidative c-h acylation of phenols with aldehydes
Lee, Hanbin,Yi, Chae S.
supporting information, p. 1899 - 1904 (2015/03/18)
The cationic ruthenium hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4- has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts. A cationic ruthenium hydride complex catalyzes the oxidative C-H coupling of phenols with aldehydes to form 2-acylphenol and flavene derivatives.
A composition for lightening skin and hair
-
, (2014/10/28)
Suggested is a composition comprising (a) sclareolide and (b1) at least one tyrosinase inhibitor; and/or (b2) at least one sun protection factor; and/or (b3) at least one anti-oxidants; and/or (b4) at least one anti-inflammatory agent; and/or (b5) at least one desquamating agent.
