42059-56-3

Upstream product

• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 57811-90-2 C₉H₉BF₂O₃ 
• 79-37-8 oxalyl dichloride 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 108-46-3 recorcinol 

Downstream Products

• 84531-15-7 4-(2-Hydroxy-4-methoxy-benzoyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 99488-17-2 4-(2-Hydroxy-4-methoxy-benzoyl)-6-(7-methoxy-4-oxo-4H-chromen-3-yl)-pyridine-2-carboxylic acid ethyl ester 
• 1033328-73-2 7-methoxy-3-[(1E)-2-phenylethenyl]-4H-1-benzopyran-4-one 
• 1173901-56-8 7-methoxychromone-3-carbaldehyde-benzoylhydrazone 
• 1160309-56-7 (Z)-4'-ethoxy-7-methoxy-3-styrylchromone 
• 1160309-57-8 (E)-3-(4-ethoxystyryl)-7-methoxy-4H-chromen-4-one 
• 1160309-49-8 (Z)-7-methoxy-3-styrylchromone 
• 1160309-64-7 (E)-7-methoxy-3-(3-nitrostyryl)-4H-chromen-4-one 
• 1160309-60-3 (E)-7-methoxy-3-(4-nitrostyryl)-4H-chromen-4-one 
• 1160309-52-3 (Z)-4'-chloro-7-methoxy-3-styrylchromone 
• 1160309-53-4 (E)-4'-chloro-7-methoxy-3-styrylchromone 
• 42059-55-2 7-hydroxy-3-formylchromone 

Relevant academic research and scientific papers

A Novel Chromone Schiff-Base Fluorescent Chemosensor for Cd(II) Based on C=N Isomerization

A new chromone Schiff-base fluorescent probe 7′-methoxychromone-3′-methylidene-1,2,4-triazole-3-imine (L) was designed and synthesized for selective recognition Cd2+. With the fluorescence titration and the ESI-MS data, we reach the conclusion that the binding mode of the ligand-metal (L-Cd2+) complex is 1:1. The sensor showed a strong fluorescence enhancement in ethanol system of Cd2+ (excitation 409?nm and emission 462?nm) and the sensing mechanism based on the fact that C=N isomerization can be used to explain this phenomenon.

A highly selective and sensitive fluorescent turn-on chemosensor for Al3+ based on a chromone Schiff base

A Schiff-base fluorescent sensor, 7-methoxychromone-3-carbaldehyde-(3,4- dimethyl)pyrrole hydrazone (MCPH), was synthesized. The new sensor showed high selectivity for Al3+ over other metal ions examined in acetonitrile. Upon binding Al3+, a significant fluorescence enhancement with a turn-on ratio over 101-fold was triggered. The detection limit of MCPH for Al3+ was 2.5107molL1.

Synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer ce

A Schiff-base receptor based chromone derivate: Highly selective fluorescent and colorimetric probe for Al(III)

Upon excitation of the visible light, probes show colorimetric and fluorescent responses to the specific metal ion, which can be easily detected by the naked eye. Owing to the excitation of the visible light at 423 nm, a novel and simple Schiff-base receptor based chromone derivative called 7-methoxychromone-3-carbaldehyde-(indole-3-formyl) hydrazone (MCIH2) had been investigated as a selective and sensitive probe for Al3+ with colorimetric and fluorescent responses. Upon addition of Al3+ to compound MCIH2 solution, compound MCIH2 could respond to Al3+ with a good selective colorimetric signal, which was easily observed from colorless to yellow-green by the naked eye. Furthermore, a remarkable fluorescence emission enhancement with an “OFF-ON” signal by over 700-fold was triggered, but other various metal ions had no such significant effects on the fluorescence emission. In addition, the detection limit of compound MCIH2 for recognizing Al3+ was evaluated to be as low as 1 × 10?7 M level, which was sufficiently low for sensing Al3+ widely distributed in various environmental and biological systems.

A novel and resumable Schiff-base fluorescent chemosensor for Zn(II)

A new resumable Schiff-base fluorescent probe 7-methoxychromone-3-carbaldehyde-(3′-hydroxy-2′-naphthaleneformyl) hydrazone (L) was designed and synthesized for selective recognition Zn2+. With the titration and the ESI-MS spectra data, we reached the conclusion that the binding ratio between L and Zn2+ was determined to be 1. The sensor showed a strong fluorescence enhancement in ethanol system of Zn2+ (excitation 430 nm and emission 498 nm). And the enhancement may be due to C=N isomerization and Photoinduced Electron Transfer (PET).

A rhodamine and chromone based “turn-on” fluorescent probe (RC1) for Zn(II) in aqueous solutions and its application

In this paper, we constructed a novel turn-on fluorescent probe 7-methoxychromone-3-carbaldehyde-(rhodamine B carbonyl) hydrazone which contains rhodamine and chromone moieties (RC1) for the detection of Zn2+. This probe processes good selectivity and high sensitivity for Zn2+ in the presence of most other metal ions except Al(III), Cr(III), Cu(II) and Fe(III), and the fluorescence property of RC1 towards Zn2+ was hardly disturbed when the concentration of Al(III), Cr(III), Cu(II) or Fe(III) was lower than 5 μM. The photoinduced electron transfer process (PET) was proposed to explain the observed spectral responses. It could be seen that the probe RC1 formed complex with Zn2+ in 1:1 ratio based on Job's plot analysis and mass spectrometry analysis. The detection limit of RC1 recognizing Zn2+ was low to 3.35 × 10?7 M. Furthermore, test strips containing the probe molecule (RC1) were easy of access and offered a practical, efficient and low-cost test tool for Zn2+.

Synthesis, crystal structure, antioxidant activities and DNA-binding studies of the Ln(III) complexes with 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone

A novel chromone Schiff base, 7-methoxychromone-3-carbaldehyde-(4′-hydroxy) benzoyl hydrazone (L) and its Ln(III) complexes (Ln = La, Eu) were synthesized and characterized. The crystal structure of the La(III) complex was determined by single-crystal X-r

A simple fluorescent-colorimetric probe for selective switch-on detection of Al3+ in ethanol

A novel and simple fluorescent probe, 7-methoxychromone-3-carbaldehyde-(3′4′5′-trimethoxybenzoyl) hydrazone (L), was designed and synthesized. The probe L presented outstanding “turn-on” fluorescence response towards Al3+ over most other competitive ions in ethanol. The detection limit of L for recognizing Al3+ was measured to be 2.14 × 10?7 M. According to these excellent properties, the detecting of Al3+ on filter papers was studied successfully. Photoinduced electron transfer (PET) process, coupled with the C[dbnd]N isomerisation process, is put forward to interpret the obvious fluorescence response.

A colorimetric and turn-on fluorescent chemosensor for Al(III) based on a chromone Schiff-base

A simple Schiff-base receptor 7-methoxychromone-3-carbaldehyde- (pyridylformyl) hydrazone (MCNH) was prepared. It exhibits an off-on-type mode with high sensitivity in the presence of Al 3+. This compound could be used as Al3+ probe in ethanol and it features visible light excitation (433 nm) and emission (503 nm) profiles. Upon binding of Al3+, a significant fluorescence enhancement with a turn-on ratio over 800-fold was triggered. However, other metal ions had no such significant effect on the fluorescence. MCNH can also be used as a colorimetric chemosensor for Al3+, which is easily observed from colorless to yellow-green by the naked-eye. The detection limit of MCNH for Al3+ was as low as 1.9 × 10-7 M.

Synthesis and biological evaluation of 3-styrylchromone derivatives as selective monoamine oxidase B inhibitors

A series of 3-styrylchromone derivatives was synthesized and evaluated for monoamine oxidase (MAO) A and B inhibitory activities. Most of all derivatives inhibited MAO-B selectively, except compound 21. Compound 19, which had a methoxy group at R2 on the chromone ring and chlorine at R4 on phenyl ring, potently inhibited MAO-B, with an IC50 value of 2.2 nM. Compound 1 showed the highest MAO-B selectivity, with a selectivity index of >3700. Further analysis of these compounds indicated that compounds 1 and 19 were reversible and mixed-type MAO-B inhibitors, suggesting that their mode of action may be through tight-binding inhibition to MAO-B. Quantitative structure–activity relationship (QSAR) analyses of the 3-styrylchromone derivatives were conducted using their pIC50 values, through Molecular Operating Environment (MOE) and Dragon. There were 1796 descriptors of MAO-B inhibitory activity, which showed significant correlations (P 50 value index exhibited a determination coefficients (R2) of 0.972 and a Leave-One-Out cross-validated determination coefficients (Q2) of 0.914. These data suggest that the 3-styrylchromone derivatives assessed herein may be suitable for the design and development of novel MAO inhibitors.