164118-40-5Relevant academic research and scientific papers
Total Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C by a Carbonyl Ylide Cycloaddition Strategy
Nakamura, Seiichi,Hirata, Yuuki,Kurosaki, Takahiro,Anada, Masahiro,Kataoka, Osamu,Kitagaki, Shinji,Hashimoto, Shunichi
, p. 5351 - 5355 (2007/10/03)
Ketal isomers avoided. The unique 2,8-dioxabicyclo[3.2.1 ]octane core of zaragozic acid C (1) was constructed in a Rh-catalyzed 1,3-dipolar cycloaddition of an alkyne to an ester carbonyl ylide. Another feature of this improved synthesis is the constructi
Synthesis of Zaragozic Acid A/Squalestatin S1
Nicolaou, K. C.,Yue, Eddy W.,Greca, Susan La,Nadin, Alan,Yang, Zhen,et al.
, p. 467 - 494 (2007/10/03)
A novel synthetic approach to the construction of the zaragozic acids, which was used for the asymmetric synthesis of zaragozic acid A/squalestatin S1 (1), is described.Fragment 5, representing the tricarboxylic acid core portion, is assembled in three ke
