164148-80-5Relevant academic research and scientific papers
Fused bicyclic Gly-Asp β-turn mimics with potent affinity for GPIIb-IIIa. Exploration of the arginine isostere
Fisher, Matthew J.,Giese, Ulrich,Harms, Cathy S.,Kinnick, Michael D.,Lindstrom, Terry D.,McCowan, Jefferson R.,Mest, Hans-Juergen,Morin Jr., John M.,Mullaney, Jeffrey T.,Paal, Michael,Rapp, Achim,Ruehter, Gerd,Ruterbories, Ken J.,Sall, Daniel J.,Scarborough, Robert M.,Schotten, Theo,Stenzel, Wolfgang,Towner, Richard D.,Um, Suzane L.,Utterback, Barbara G.,Wyss, Virginia L.,Jakubowski, Joseph A.
, p. 385 - 389 (2007/10/03)
6-[4-Amidinobenzoyl]amino]-tetralone-2-acetic acid is a potent antagonist of GPIIb-IIIa. Substitution in the meta position of the benzamidine, or replacement with a heteroaryl amidine was tolerated in this series. Use of an acyl-linked 4-alkyl piperidine
