164150-99-6

Upstream product

• 109-01-3 1-methyl-piperazine 
• 193884-05-8 1-(5-fluoro-2-pyridyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 164151-32-0 ethyl 3-(5-fluoro-2-pyridyl)amino-2-(2,4,5-trifluorobenzoyl)acrylate 
• 164151-07-9 ethyl 1-(5-fluoro-2-pyridyl)-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate 
• 101799-75-1 α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester 
• 98349-24-7 ethyl 2,4,5-trifluorobenzoylacetate 

Relevant academic research and scientific papers

NOVEL QUINOLONE CARBOXYLIC ACID DERIVATIVES

The present invention relates to the novel quinolone carboxylic acid derivatives of the following formula (I) and their pharmaceutically acceptable salts and their hydrates. (I) wherein X is a hydrocarbon, fluorocarbon or nitrogen atom, Y is a hydrogen or methyl group, R1 is a hydrogen or alkyl group having 1 to 5 carbon atom, R2 is wherein A and B is a fluorocarbon or nitrogen atom, provided that, if A=CF, B=N and if A=N, B=CF) and R3 is (wherein R4 is an amino group which makes a racemate or (S)-enantiomer) or (wherein R5, R6 and R7 are respectively hydrogen or alkyl group having 1 to 3 carbon atom.). The compounds according to the present invention are used as antibacterial agents.

Synthesis, pharmacokinetics, and biological activity of a series of new pyridonecarboxylic acid antibacterial agents bearing a 5-fluoro-2-pyridyl group or a 3-fluoro-4-pyridyl group at n-1

The 1-(5-fluoro-2-pyridyl) or 1-(3-fluoro-4-pyridyl) group was introduced in the syntheses of new pyridonecarboxylic acid antibacterial agents. 1-(5-Fluoro-2-pyridyl)-6-fluoro-1,4-dihydro-7-(4-methyl-1- piperazinyl)-4-oxoquinolone-3-carboxylic acid 7b (DW

Quinolone carboxylic acid derivatives

The present invention relates to the novel quinolone carboxylic acid derivatives of the following formula (I) and their pharmaceutically acceptable salts and their hydrates. STR1 wherein X is a hydrocarbon, fluorocarbon or nitrogen atom, Y is a hydrogen or methyl group, R1 is a hydrogen or alkyl group having 1 to 5 carbon atom, R2 is STR2 wherein A and B is a fluorocarbon or nitrogen atom, provided that, if A=CF, B=N and if A=N, B=CF) and R3 is STR3 (wherein R4 is an amino group which makes a racemate or (S)-enantiomer) or STR4 (wherein R5, R6 and R7 are respectively hydrogen or alkyl group having 1 to 3 carbon atom.). The compounds according to the present invention are used as antibacterial agents.