164160-64-9

Upstream product

• 164160-59-2 3-{1-[(E)-Hydroxyimino]-octadecyl}-1H-indole-2-carboxylic acid ethyl ester 
• 164160-98-9 3-Octadecanoyl-1H-indole-2-carboxylic acid ethyl ester 
• 645-45-4 hydrocinnamic acid chloride 
• 57-11-4 stearic acid 
• 3770-50-1 2-carbethoxyindole 
• 80-48-8 methyl p-toluene sulfonate 
• 164160-61-6 3-[1-(3-Phenyl-propionylamino)-octadecyl]-1H-indole-2-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

3-(Octadecanoylaminomethyl)indol-e-2-carboxylic acid derivatives and 1-methyl-3-octadecanoylindole-2-carboxylic acid as inhibitors of cytosolic phospholipase A2

3-(1-Acylaminooctadecyl)indole-2-carboxylic acids and 3-(1-acylaminooctadecyl)-1-methylindole-2-carboxylic acids were designed and synthesized as inhibitors of cytosolic phospholipase A2. Enzyme inhibition was assayed by evaluation of calcium ionophore A23187-induced arachidonic acid release from bovine platelets. While compounds with 1-octadecanoylaminooctadecyl groups in position 3 of the indole were inactive inhibition data for 3-[1-(3-phenylpropionylamino)octadecyl]indole-2-carboxylic acids could not be evaluated because of lysis of the platelets. However 3-(octadecanoylaminomethyl)indole-2-carboxylic acid derivatives and 1-methyl-3-octadecanoylindole-2-carboxylic acid proved to be inhibitors of cytosolic phospholipase A2. The most active inhibitor was the latter compound with an IC50 of 8 μM.