164172-25-2

Upstream product

• 164172-23-0 (2R,3R)-syn-N-(4-methoxybenzyl)-2-ethyl-3-methylpent-4-yne carboxamide 
• 164172-16-1 1,9-diiodo-3,7-bis[2-(methoxycarbonyl)ethyl]-2,8-dimethyldipyrrin 
• 809-27-8 4,4'-bis-(2-methoxycarbonyl-ethyl)-3,3'-dimethyl-5,5'-methanediyl-bis-pyrrole-2-carboxylic acid 
• 2393-23-9 4-methoxy-benzylamine 
• 130468-97-2 3-{5-Iodo-2-[5-iodo-3-(2-methoxycarbonyl-ethyl)-4-methyl-1H-pyrrol-2-ylmethyl]-4-methyl-1H-pyrrol-3-yl}-propionic acid methyl ester 
• 992-36-9 dibenzyl 3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 20303-31-5 benzyl 4-(2-methoxycarbonylethyl)-3,5-dimethylpyrrole-2-carboxylate 
• 164172-24-1 C₅₁H₆₂N₄O₉ 

Relevant academic research and scientific papers

New Strategies for the Synthesis of Biologically Important Tetrapyrroles. The "B,C + D + A" Approach to Linear Tetrapyrroles

Linear tetrapyrroles related to phytochrome (1) were prepared in enantiospecific fashion by a new strategy beginning with ring-B,C synthons of type 19 (bis-iododipyrrins). Rings A and D were elaborated by Pd(0)-mediated coupling of 19a with the appropriate alkyne acid or amide derivatives 9 and 20, followed by intramolecular cyclization (method C: BC + D + A → ABCD).

A Conceptually New Approach to the Synthesis of Linear Tetrapyrroles Related to Phytochrome

Linear tetrapyrroles 9, of a type related to phytochrome (3), have been prepared by TBAF catalyzed 5-exo-dig cyclization of bis-acetylenic amides 8.