164178-33-0 Usage
Uses
Used in Oncology:
AM 630 is used as a CB2 receptor antagonist for human lung cancer treatment, as it has been shown to inhibit tumor growth and angiogenesis induction, which are critical processes for cancer progression.
Used in Pain Management Research:
AM 630 is used as a cannabinoid 2 (CB2) inhibitor to study the analgesic effects exerted by polysaccharopeptide from Trametes versicolor (TPSP), a medicinal mushroom with potential pain-relieving properties.
Used in Wound Healing Studies:
AM 630 is used as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithelialization of fibroblast cells, a process crucial for wound healing and tissue regeneration.
Used in Osteoblast Research:
AM 630 is used as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts, which can provide insights into the role of CB2 receptors in bone metabolism and the potential for developing new treatments for bone-related disorders.
Biological Activity
CB 2 antagonist/inverse agonist (K i = 31.2 nM) that displays 165-fold selectivity over CB 1 receptors. Behaves as a weak partial/inverse agonist at CB 1 receptors.
Biochem/physiol Actions
AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).
references
1. ross r a, brockie h c, stevenson l a, et al. agonist-inverse agonist characterization at cb1 and cb2 cannabinoid receptors of l759633, l759656 and am630. british journal of pharmacology, 1999, 126(3): 665-672. 2. patil m, patwardhan a, salas m m, et al. cannabinoid receptor antagonists am251 and am630 activate trpa1 in sensory neurons. neuropharmacology, 2011, 61(4): 778-788.
Check Digit Verification of cas no
The CAS Registry Mumber 164178-33-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,4,1,7 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 164178-33:
(8*1)+(7*6)+(6*4)+(5*1)+(4*7)+(3*8)+(2*3)+(1*3)=140
140 % 10 = 0
So 164178-33-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
