164223-99-8

Upstream product

• 54731-09-8 N-tosyl-L-prolyl chloride 
• 243870-15-7 (17R,S)-17-hydroxy-14,15-secoandrost-4-en-15-yn-3-one 
• 164223-96-5 <4'aR-(4'aα,4'bβ,7'β,8'aα)>-3',4',4'a,4'b,5',6',7',8',8'a,9'-decahydro-4'a,7'-dimethylspiro-<1,3-dioxolane-2,2'(1'H)-phenanthrene>-7'-carboxaldehyde 
• 114549-29-0 <2S-(2α,4aα,4bβ,10aβ)>-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-2,4b-dimethyl-7-oxo-2-phenanthrenecarboxylic acid methyl ester 
• 114549-30-3 <2S-(2α,4aα,4bβ,10aβ)>-1,2,3,4,4a,4b,7,9,10,10a-decahydro-2,4b-dimethyl-7-oxo-2-phenanthrenecarboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis of (17R)- and (17S)- 17-hydroxy- 14, 15-secoandrost-4-en-15-yn- 3-one and the X-ray crystal structure of the (17S)-diastereomer

(17R,S)-17-Hydroxy-14,15-secoandrost-4-en-15-yn-3-one has been shown previously to be a mechanism-based inactivator of rat liver 3α- hydroxysteroid dehydrogenase. This manuscript describes the synthesis of this diastereomeric 14,15-secosteroid from [2S-(2

Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-16-yn-3- one and the X-ray crystal structure of the (17S)-diastereomer

(17R, S)-17-Hydroxy-14,15-secoandrost-4-en-15-yn-3-one has been shown previously to be a mechanism-based inactivator of rat liver 3α- hydroxysteroid dehydrogenase. This manuscript describes the synthesis of this diastereomeric 14,15-secosteroid from [2S-2