54731-09-8Relevant articles and documents
Stereoselective total synthesis of (S)- and (R)-nuciferine using benzyne chemistry
Casagrande, Gleison A.,Deflon, Victor M.,Martins, Gabriel R.,Oliveira-Silva, Diogo,Perecim, Givago P.,Pinto, Leandro M. C.,Raminelli, Cristiano
, (2020/08/13)
Total syntheses of (S)- and (R)-nuciferine were accomplished through approach involving diastereoselective reaction between a chiral dihydroisoquinoline enamide and 2-(trimethylsilyl)phenyl trifluoromethanesulfonate promoted by CsF, affording a separable mixture of diastereoisomers, which provided (S)- and (R)-nuciferine via simple and efficient transformations.
Structure-Activity Relationship Studies with Tetrahydroquinoline Analogs as EPAC Inhibitors
Sonawane, Yogesh A.,Zhu, Yingmin,Garrison, Jered C.,Ezell, Edward L.,Zahid, Muhammad,Cheng, Xiaodong,Natarajan, Amarnath
supporting information, p. 1183 - 1187 (2017/11/15)
EPAC proteins are therapeutic targets for the potential treatment of cardiac hypertrophy and cancer metastasis. Several laboratories use a tetrahydroquinoline analog, CE3F4, to dissect the role of EPAC1 in various disease states. Here, we report SAR studies with tetrahydroquinoline analogs that explore various functional groups. The most potent EPAC inhibitor 12a exists as a mixture of inseparable E (major) and Z (minor) rotamers. The rotation about the N-formyl group indeed impacts the activity against EPAC.
High-Performance Isocyanide Scavengers for Use in Low-Waste Purification of Olefin Metathesis Products
Szczepaniak, Grzegorz,Urbaniak, Katarzyna,Wierzbicka, Celina,Kosiński, Krzysztof,Skowerski, Krzysztof,Grela, Karol
, p. 4139 - 4148 (2015/12/30)
Three isocyanides containing a tertiary nitrogen atom were investigated for use as small-molecule ruthenium scavenging agents in the workup of olefin metathesis reactions. The proposed compounds are odorless, easy to obtain, and highly effective in removi
