164229-00-9

Upstream product

• 164228-91-5 <1S,2S,3aS,7aR>-1,5,5-trimethyl-2-phenylmethoxymethyl-4,6-dioxa-(2,3,3a,4,5,6,7,7a)octahydroindene 
• 164228-88-0 methyl (4S,5R)-2,2-dimethyl-5-ethyl-1,3-dioxane-4-propionate 
• 164228-90-4 methyl <1S,2S,3aS,7aR>-1,5,5-trimethyl-4,6-dioxa-(2,3,3a,4,5,6,7,7a)octahydroindene-2-carboxylate 
• 164228-89-1 methyl (4S,5R)-α-diazo-2,2-dimethyl-5-ethyl-1,3-dioxanepropionate 
• 164228-87-9 (4S,5R)-2,2-dimethyl-5-ethyl-5-(4-methyl-3-pentenyl)-1,3-dioxane 
• 164228-96-0 methyl (2S,3S)-2-ethyl-3-hydroxy-7-methyl-6-octenoate 
• 164228-99-3 ((4aR,5R,6S,7aS)-2,2,5-Trimethyl-hexahydro-cyclopenta[1,3]dioxin-6-yl)-methanol 
• 164228-97-1 (2R,3S)-2-Ethyl-7-methyl-oct-6-ene-1,3-diol 
• 135191-38-7 methyl (S)-3-hydroxy-7-methyl-6-octenoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 164228-92-6 (1S,2R,3R,4S)-3-methyl-2-(4-methylbenzylsulfonyloxy methyl)-4-(phenylmethoxy)cyclopentanol 
• 164229-03-2 ((2S,3S,3aS,6S,8aR,9S,9aR)-2-Benzyloxymethyl-3,6-dimethyl-dodecahydro-4a-aza-cyclopenta[b]naphthalen-9-yl)-methanol 
• 164228-95-9 (2S,3S,3aS,6S,8aR,9S,9aR)-2-Benzyloxymethyl-3,6-dimethyl-dodecahydro-4a-aza-cyclopenta[b]naphthalene-9-carboxylic acid ethyl ester 
• 164229-04-3 (2S,3S,3aS,6S,8aR,9S,9aR)-2-Benzyloxymethyl-3,6-dimethyl-9-phenylsulfanylmethyl-dodecahydro-4a-aza-cyclopenta[b]naphthalene 
• 164228-94-8 [(2R,5S)-1-((1R,2R,3S,5S)-3-Benzyloxymethyl-5-hydroxy-2-methyl-cyclopentylmethyl)-5-methyl-piperidin-2-yl]-acetic acid ethyl ester 

Relevant academic research and scientific papers

Highly diastereoselective cyclopentane construction: Enantioselective synthesis of the dendrobatid alkaloid 251F

We report the first total synthesis, and thus structural confirmation, of the dendrobatid alkaloid 251F (1), based on the retrosynthetic analysis illustrated (1 → → 4). Key observations in this synthesis are that both the Rh-mediated cyclization of 4 and