16424-76-3

Upstream product

• 264620-50-0 2-hydroxy-3,3-dimethyl-cyclopentanone 
• 108-91-8 cyclohexylamine 
• 79-50-5 pantolactone 

Downstream Products

• 100396-14-3 phosphoric acid mono-(3-cyclohexylcarbamoyl-3-hydroxy-2,2-dimethyl-propyl ester) 
• 111473-98-4 phosphoric acid benzyl ester-(3-cyclohexylcarbamoyl-3-hydroxy-2,2-dimethyl-propyl ester) 
• 115018-83-2 1-cyclohexyl-4,4-dimethylpyrrolidine-2,3,5-trione 
• 886616-34-8 toluene-4-sulfonic acid 1-cyclohexyl-4,4-dimethyl-2-oxo-pyrrolidin-3-yl ester 
• 122724-15-6 diphosphoric acid mono-(3-cyclohexylcarbamoyl-3-hydroxy-2,2-dimethyl-propyl ester) 

Relevant academic research and scientific papers

CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

The present invention discloses compounds of Formula I: (I) having 11beta -HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

Enantioselective hydrogenation of pyrrolidine-2,3,5-triones over the Pt- cinchonidine system

1- and 4-Substituted pyrrolidine-2,3,5-triones 5, 6 and 9 have been synthesized and hydrogenated to 3-hydroxy derivatives 10-12 with 17-91% ee using a 5 wt% Pt/Al2O3 catalyst in the presence of small amounts of cinchonidine. The infl