164254-07-3Relevant academic research and scientific papers
Comparison of two amides as backbone replacement of the phosphodiester linkage in oligodeoxynucleotides
Lebreton, Jacques,Waldner, Adrian,Fritsch, Valerie,Wolf, Romain M.,De Mesmaeker, Alain
, p. 5225 - 5228 (1994)
The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.
