Comparison of two amides as backbone replacement of the phosphodiester linkage in oligodeoxynucleotides

DOI: 10.1016/S0040-4039(00)77069-9

Source and publish data:

Tetrahedron Letters p. 5225 - 5228 (1994)

Update date:2022-07-30

Topics:

Authors:

Lebreton, Jacques

Waldner, Adrian

Fritsch, Valerie

Wolf, Romain M.

De Mesmaeker, Alain

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)77069-9

The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.

Full text of DOI:10.1016/S0040-4039(00)77069-9

Products guided by the article

Product name:1-[(2R,4S,5R)-4-(tert-Butyl-diphenyl-silanyloxy)-5-[1,3]dithian-2-ylidenemethyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Cas No:164254-07-3

R&D Labs maybe for 164254-07-3

Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
Meryer (Shanghai) Chemical Technology Co., Ltd.

website:http://www.meryer.com/cn/index/

Contact:+86-755-86170518

Address:Minhang,Shanghai, China
Taimai Sanluck Pharmaceutical Co.,Ltd

Contact:86-592-7662921

Address:8D,No.186,Huarong Road,Huli,Xiamen,China
Hangzhou Eastbiopharm Co.,Ltd.

Contact:+86-571-88931780

Address:Hangzhou,China
Huixian Tiankai Paper Making Agent CO.,Ltd.

Contact:+86-373-6899808

Address:Mengdian Industrial Avenue,Huixian,Xinxiang,Henan,China

Relevant to this article

Unusual reaction of 1,4-diamino-2-nitrobenzene derivatives toward nucleophiles: Catalysis by sodium sulphite

Doi:10.1016/S0040-4020(98)00181-1
(1998)
2-Methylimidazole does not bind to (octaethylporphinato)iron(III) chloride in the presence of methanol: A resonance raman study

Doi:10.1021/ja00088a068
(1994)
A new procedure for the synthesis of C-glycosides of nojirimycin

Doi:10.1039/b003877f
(2000)
Determination of the binding of ligands containing the N-2,4-dinitrophenyl group to bivalent monoclonal rat anti-DNP antibody using affinity capillary electrophoresis

Doi:10.1021/ac00115a023
(1995)
Terpenoids. XXXIII. Chemical conversion of enmein into enmelol

Doi:10.1248/cpb.23.858
(1975)
Crystal structure of K₂[C₂O₆] - First proof of existence and constitution of a peroxodicarbonate ion

Doi:10.1002/1521-3773(20020603)41:11<1922::AID-ANIE1922>3.0.CO;2-T
(2002)

Article Doi