Comparison of two amides as backbone replacement of the phosphodiester linkage in oligodeoxynucleotides

DOI: 10.1016/S0040-4039(00)77069-9

Source and publish data:

Tetrahedron Letters p. 5225 - 5228 (1994)

Update date:2022-07-30

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Authors:

Lebreton, Jacques

Waldner, Adrian

Fritsch, Valerie

Wolf, Romain M.

De Mesmaeker, Alain

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Article abstract of DOI:10.1016/S0040-4039(00)77069-9

The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.

Full text of DOI:10.1016/S0040-4039(00)77069-9

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