1642594-41-9Relevant articles and documents
A convenient enantioselective decarboxylative aldol reaction to access chiral a-hydroxy esters using β-keto acids
Duan, Zhiqiang,Han, Jianlin,Qian, Ping,Zhang, Zirui,Wang, Yi,Pan, Yi
supporting information, p. 969 - 974 (2014/05/20)
We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral a-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic a-keto esters. The possible mechanism is rationalized.