13422-78-1

Basic information

• Product Name: 3-oxo-3-p-toluoylpropanoic acid
• Synonyms: 3-oxo-3-p-toluoylpropanoic acid
• CAS NO: 13422-78-1
• Molecular Weight: 178.188
• Mol File: 13422-78-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-oxo-3-p-toluoylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-oxo-3-p-toluoylpropanoic acid(13422-78-1)
• EPA Substance Registry System: 3-oxo-3-p-toluoylpropanoic acid(13422-78-1)

Safety Data

• Hazardous Substances Data: 13422-78-1(Hazardous Substances Data)

Upstream product

• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 1476-39-7 1,5-diaminopentane dihydrochloride 
• 333-93-7 putrescine dihydrochloride 
• 122-00-9 para-methylacetophenone 
• 874-60-2 4-methyl-benzoyl chloride 
• 22027-51-6 3-oxo-3-p-tolyl-propionic acid methyl ester 
• 18457-04-0 bis(trimethylsilyl) malonate 

Downstream Products

• 122-00-9 para-methylacetophenone 
• 1392149-62-0 (3R)-tert-butyl 3-hydroxy-2-oxo-3-(2-oxo-2-(p-tolyl)ethyl)-2,3-dihydro-1H-indoline-1-carboxylate 
• 1415726-80-5 (S)-3-benzyl-3-(2-oxo-2-(p-tolyl)ethyl)indolin-2-one 
• 3422-75-1 3-oxo-N-phenyl-3-(p-tolyl)propanamide 
• 1436432-55-1 3-hydroxy-4-p-tolylquinolin-2(1H)-one 
• 1447666-74-1 4-methyl-N-(3-oxo-1-phenyl-3-(p-tolyl)propyl)benzenesulfonamide 
• 70452-25-4 3-hydroxy-3-[2-(4-methylphenyl)-2-oxoethyl]-2-oxindole 
• 1459140-98-7 C₂₄H₂₁NO₃ 
• 1604833-34-2 (R)-2-(2,2-dioxido-3,4-dihydrobenzo[e][1,2,3]oxathiazin-4-yl)-1-(p-tolyl)ethanone 
• 1642594-41-9 C₁₉H₂₀O₄ 

Relevant articles and documents

Enantioselective decarboxylative Mannich reaction of β-keto acids withC-alkynylN-BocN,O-acetals: access to chiral β-keto propargylamines

The chiral keto-substituted propargylamines are an essential class of multifunctional compounds in the field of organic and pharmaceutical synthesis and have attracted considerable attention, but the related synthetic approaches remain limited. Therefore, a concise and efficient method for the enantioselective synthesis of β-keto propargylaminesviachiral phosphoric acid-catalyzed asymmetric Mannich reaction between β-keto acids andC-alkynylN-BocN,O-acetals as easily availableC-alkynyl imine precursors has been demonstrated here, affording a broad scope of β-ketoN-Boc-propargylamines in high yields (up to 97%) with generally high enantioselectivities (up to 97?:?3 er).

Double decarboxylative route to 3-substituted pyrrolidines: Reaction of monoalkyl malonates and related carboxylic acids with sarcosine and formaldehyde

Three-component reactions of monoalkyl malonates, cyanoacetic acids or 2-ketocarboxylic acids, N-methylglycine, and formaldehyde were developed to rapidly access 3-substituted pyrrolidines in 17–97% yield. These reactions represent a double decarboxylative domino-sequence promoted by pyrrolidine and involve N-methylazomethine ylide as the reactive intermediate.

Synthesis of novel proxyphylline derivatives with dual Anti-Candida albicans and anticancer activity

Three out of 16 newly synthesized 1,3-dimethylxanthine derivatives (proxyphylline analogues) exhibited consistencies between antifungal and anticancer properties. Proxyphylline possessing 1-(10H-phenothiazin-10-yl)propan-2-yl (6) and polybrominated benzimidazole (41) or benzotriazole moiety (42) remained selectively cidal against Candida albicans (lg R ≥ 3 at conc. of 31, 36 and 20 μM, respectively) however not against normal mammalian Vero cell line in vitro (IC50 ≥ 280 μM) and Galleria mellonella in vivo. These compounds also displayed moderate antineoplastic activity against human breast adenocarcinoma (MCF-7) cell line (EC50 = 80 μM) and high against peripheral blood T lymphoblast (CCRF-CEM) (EC50 = 6.3–6.5 μM). In addition, 6 and 42 exerted: (1) dual activity against fungal adhesion and damage mature biofilm; (2) necrosis of planktonic cells due to loss of membrane function and of structural integrity; (3) biochemical (inhibition of sessile cell respiration) and morphological changes in cell wall polysaccharide contents. Therefore, leading proxyphylline derivatives can be employed to prevent cancer-associated biofilm Candida infections.