1642811-75-3Relevant academic research and scientific papers
Substituted pyrimidinetrione compound, composition containing same and application of substituted pyrimidinetrione compound
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, (2018/11/22)
The invention provides a substituted pyrimidinetrione compound, a composition containing the same and application of the substituted pyrimidinetrione compound. The invention discloses the pyrimidinetrione compound as shown in formula (I) or the crystal form, pharmaceutically acceptable salt, prodrug, stereisomer, hydrate or solvent compound thereof. The pyrimidinetrione compound and the composition containing the same can be used for regulating hypoxia-inducible factors (HIF) and/or erythropoietin (EPO) and can be used for preparing medicine for regulating and controlling human body anemia.
Transition state analysis of enantioselective br?nsted base catalysis by chiral cyclopropenimines
Bandar, Jeffrey S.,Sauer, Gregory S.,Wulff, William D.,Lambert, Tristan H.,Vetticatt, Mathew J.
supporting information, p. 10700 - 10707 (2014/08/18)
Experimental 13C kinetic isotope effects have been used to interrogate the rate-limiting step of the Michael addition of glycinate imines to benzyl acrylate catalyzed by a chiral 2,3-bis(dicyclohexylamino) cyclopropenimine catalyst. The reaction is found to proceed via rate-limiting carbon-carbon bond formation. The origins of enantioselectivity and a key noncovalent CH?O interaction responsible for transition state organization are identified on the basis of density functional theory calculations and probed using experimental labeling studies. The resulting high-resolution experimental picture of the enantioselectivity-determining transition state is expected to guide new catalyst design and reaction development.
