164322-91-2Relevant academic research and scientific papers
Lipase-catalyzed hydrolysis of 2-(4-hydroxyphenyl)propionic acid ethyl ester to (R)-(?)-2-(4-hydroxyphenyl)propanoic acid
Yuan, Xin,Zhang, Panliang,Liu, Guangyong,Xu, Weifeng,Tang, Kewen
, p. 2461 - 2468 (2019/07/16)
Stereoselective hydrolysis of (±)-2-(4-hydroxyphenyl)propionic acid ethyl ester (2-HPPAEE) by lipase catalyzed in aqueous system was investigated. Lipase AK with higher catalytic activity and enantioselectivity was selected as catalyst. Simultaneously, factors affecting the conversion of substrate (c) and the enantiomeric excess of product (eep) were optimized. The optimal conditions were established, involving 45?°C of temperature, 5.5 of pH, 10?mg of lipase AK dosage, 0.04?mmol of substrate dosage and 40?h of reaction time. Under the optimum conditions, c and eep could reach up to 49% and 98%, respectively.
PROPIONIC ACID DERIVATIVE
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, (2008/06/13)
A propionic acid derivative represented by general formula (I) or a pharmaceutically acceptable acid-addition salt thereof, wherein A represents OH, C1-C8 lower alkoxy, -NR1R2, or C1-C8 lower alkoxy which may be substituted by halogen, optionally susbtitu
