1643336-80-4Relevant academic research and scientific papers
Asymmetric Ugi 3CR on isatin-derived ketimine: Synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives
Lesma, Giordano,Meneghetti, Fiorella,Sacchetti, Alessandro,Stucchi, Mattia,Silvani, Alessandra
, p. 1383 - 1389 (2014)
An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed. The reactions proceeded smoothly and in a stereocontrolled manner with regard to the new center of the Ugi products due to the stereoinduction of the amine chiral residue. A wide variety of novel chiral 3,3-disubstituted 3-aminooxindoles were obtained, a selection of which were subjected to post-Ugi transformations, paving the way to application as peptidomimetics. 2014 Lesma et al;.
