1643360-07-9Relevant academic research and scientific papers
Regiocontrolled palladium-catalyzed and copper-mediated C-H bond functionalization of protected l-histidine
Mahindra, Amit,Jain, Rahul
supporting information, p. 3792 - 3796 (2014/06/09)
We describe the controlled and regioselective transition-metal-catalyzed C-H bond arylation of protected l-histidine with aryl halides as the coupling partner. Using this approach, a large number of C-2 arylated l-histidines have been synthesized with diverse substitutions bearing electron-donating and electron-withdrawing groups, in good to excellent yields. These synthetic amino acids possessing dual hydrophobic-hydrophilic character are important synthons of bioactive peptidomimetics, which are imperative potent inhibitors of Cryptococcus neoformans. This journal is the Partner Organisations 2014.
