164360-01-4Relevant academic research and scientific papers
Direct C-H arylation of purines: Development of methodology and its use in regioselective synthesis of 2,6,8-trisubstituted purines
Cerna, Igor,Pohl, Radek,Klepetarova, Blanka,Hocek, Michal
, p. 5389 - 5392 (2007/10/03)
Direct C-H arylation of purines to position 8 by diverse aryl iodides was achieved with Pd catalysis in the presence of CuI and Cs2CO 3. The methodology is general and efficient and was applied in the consecutive regioselective synth
The Suzuki-Miyaura cross-coupling reactions of 2-, 6- or 8-halopurines with boronic acids leading to 2-, 6- or 8-aryl- and -alkenylpurine derivatives
Havelkova,Dvorak,Hocek
, p. 1704 - 1710 (2007/10/03)
The Suzuki-Miyaura cross-coupling reactions of 9-benzyl-6-chloropurine, 9- or 3-benzyl-8-bromoadenine and 2,6-dihalopurines with boronic acids gave the corresponding 6-, 8- or 2-aryl- or -alkenylpurines in good yields. Anhydrous conditions in toluene were
Regiochemistry in Stille couplings of 2,6-dihalopurines
Langli, Geir,Gundersen, Lise-Lotte,Rise, Frode
, p. 5625 - 5638 (2007/10/03)
The regiochemistry in Stille couplings of 2,6-dihalopurines have been studied. 2,6-Dichloropurines react selectively in the 6-position, and 6-chloro-2-iodopurines and 2-bromo-6-chloropurines in the 2-position.
Regioselective Pd-mediated coupling between 2,6-dichloropurines and organometallic reagents
Gundersen, Lise-Lotte,Langli, Geir,Rise, Frode
, p. 1945 - 1948 (2007/10/02)
Selective coupling in the purine 6-position has been achieved, by reacting N-benzylated 2,6-dichloropurines with organotin and organozinc reagents. The positional identity of the products were established from long range HETCOR or nOe NMR experiments.
