16437-66-4

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 2209-60-1 4-phenyl-[1,2,4]triazolidine-3,5-dithione 
• 5373-68-2 5-amino-4-phenyl-2,4-dihydro-[1,2,4]triazolidine-3-thione 
• 21123-44-4 2-Amino-5-phenylamino-1,3,4-thiadiazole 
• 32873-56-6 2-acetamido-5-mercapto-1,3,4-thiazole 
• 14132-84-4 4?phenyl?3?(phenylamino)?1H?1,2,4?triazole?5(4H)?thione 
• 5373-68-2 3-amino-4-phenyl-Δ²-1,2,4-triazoline-5-thione 
• 14731-48-7 5-benzylthio-2-phenylamino-1,3,4-thiadiazole 
• 50432-47-8 (5-Ethylsulfanyl-[1,3,4]thiadiazol-2-yl)-phenyl-amine 
• 5585-21-7 (5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-phenyl-amine 
• 1114453-06-3 ethyl 5-amino-6-cyano-2-(phenylamino)-6(H)-1,3,4-thiadiazine-6-carboxylate 
• 1114452-97-9 2-(phenylamino)imidazo[2,1-b][1,3,4]thiadiazole-5,6-dicarbonitrile 
• 1114453-00-7 1,2-bis[5-(phenylamino)-1,3,4-thiadiazol-2-yl]hydrazine 
• 1114453-09-6 {5-amino-6-cyano-2-(phenylamino)spiro[1,3,4]thiadiazolo[3,2-a]pyrimidine-7,1'-cyclohexa[2,5]dien-4'-ylidene}malononitrile 
• 1114453-12-1 1,4-diamino-5-cyano-9-(dicyanomethylene)-N-phenyl-2,3-diazaspiro[5.5]undeca-1,4,7,10-tetraene-9-thioamide 

Relevant academic research and scientific papers

SYNTHESIS OF SOME 6-ARYLAMINO-3-AMINO-1,2,4,5-DITHIADIAZINES

The synthesis of some new 6-arylamino-3-amino-1,2,4,5-dithiadiazines (IIIa-e) has been achieved by following a novel route.

Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas

Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.