5373-68-2

Upstream product

• 79-19-6 thiosemicarbazide 
• 62-53-3 aniline 
• 16437-66-4 1-phenyl-2,5-dithiobiurea 
• 103-72-0 phenyl isothiocyanate 
• 64-17-5 ethanol 
• 79-17-4 aminoguanidine 
• 7722-84-1 dihydrogen peroxide 
• 7803-57-8 hydrazine hydrate 
• 142-46-1 bithiourea 
• 420-04-2 CYANAMID 
• 105941-44-4 phenylthiosemicarbazide hydrochloride 
• 79010-52-9 5-S-benzyliso-1-phenyl-2-thiohydrazodicarbonamide 
• 79010-51-8 C₁₀H₁₄N₄S₂ 
• 79010-50-7 C₉H₁₂N₄S₂ 

Downstream Products

• 97244-99-0 5-(methylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-amine 
• 1214883-48-3 5-(4-chlorobenzylideneamino)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 1214883-50-7 5-(2-chlorobenzylideneamino)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 1214883-49-4 5-(3-nitrobenzylideneamino)-4-phenyl-4H-1,2,4-triazole-3-thiol 
• 1214883-47-2 5-(4-nitrobenzylideneamino)-4-phenyl-4H-1,2,4-triazole-3-thiol 

Relevant academic research and scientific papers

The reactions of hydroiodide of 2-amino-1-substituted guanidine derivatives with aromatic isothiocyanates

In the reaction of hydroiodide of methyl ester of S-methylthio-semicarbazide with primary amines hydroiodides of 2-amino-1-substitutedguanidine were obtained (1). These compounds were then converted to respective 3-arylamino-4-substituted Δ2-1,2,4-triazoline-5-thione and 3- benzylamino-4-substituted Δ2-1,2,4 -triazoline-5-thione (2) in the reactions with isothiocyanates.

Reaction of 4-Alkyl/arylthiosemicarbazides with Cyanamide

The condensation of cyanamide with 4-alkyl/arylthiosemicarbazide hydrochlorides (I.HCl) results in the formation of 2-alkyl/arylamino-5-amino-1,3,4,-thiadiazoles (III) and 3-amino-4-alkyl/aryl-5-mercapto-1,2,4-triazoles (IV).

Oxidation and Eliminative Cyclisation of S-Alkylisodithiobiureas

Isothiocyanates condense with S-alkylisothiosemicarbazides to yield S-alkylisodithiobiureas.These undergo cyclisation to give 3-amino-5-mercapto-4-substituted-1,2,4-triazoles with the elimination of alkyl mercaptan on heating under neutral conditions, whereas under acidic conditions, by elimination of ammonia 5-alkylmercapto-2-substituted amino-1,3,4-thiadiazoles are formed.Condensation of isothiocyanates with thiosemicarbazides in the presence of alkali affords 1-substituted dithiobiureas.Alkylation of these dithiobiureas with alkyl halides results in the formation of 5-alkylmercapto-2-substituted-amino-1,3,4-thiadiazoles, any intermediateproduct not being isolable.On the other hand, oxidation of 1-substituted dithiobiureas with either hydrogen peroxide or iodine furnishes 2-amino-5-substituted-amino-1,3,4-thiadiazoles.