164388-42-5Relevant articles and documents
Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa
Mederski, Werner W. K. R.,Dorsch, Dieter,Anzali, Soheila,Gleitz, Johannes,Cezanne, Bertram,Tsaklakidis, Christos
, p. 3763 - 3769 (2004)
Neutral weak halothiophene benzimidazole inhibitors of the serine protease factor Xa were identified via screening of a compound library. The X-ray crystal structure of representative 3a bound to human fXa confirmed the S1 binding mode. Starting from 3a a