164456-75-1

Basic information

• Product Name: R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE
• Synonyms: R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE;1-tert-butyl 2-Methyl (2R)-piperidine-1,2-dicarboxylate;Boc-D-piperidine-2-carboxylic acid Methyl ester;Boc-R-piperidine-2-carboxylic acid Methyl ester;(R)-1-tert-Butyl 2-Methyl piperidine-1,2-dicarboxylate;Methyl (R)-1-Boc-2-piperidinecarboxylate
• CAS NO: 164456-75-1
• Molecular Formula: C₁₂H₂₁NO₄
• Molecular Weight: 243.29944
• Mol File: 164456-75-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 307.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -3.28±0.40(Predicted)
• CAS DataBase Reference: R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(164456-75-1)
• EPA Substance Registry System: R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE(164456-75-1)

Safety Data

• Hazardous Substances Data: 164456-75-1(Hazardous Substances Data)

Usage

General Description

R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE is a chemical compound that is commonly used in organic synthesis and medicinal chemistry. Its chemical structure consists of a piperidine ring with a BOC (tert-butoxycarbonyl) protecting group attached to the nitrogen atom and a carboxylic acid group at the 2-position. R-METHYL 1-BOC-PIPERIDINE-2-CARBOXYLATE is an important building block for the synthesis of various pharmaceuticals, agrochemicals, and other bioactive molecules. It is often used as a precursor in the preparation of key intermediates for the synthesis of drugs and other important compounds. Its versatility and functional groups make it a valuable tool in the development of new chemicals and pharmaceuticals.

Upstream product

• 1723-00-8 (R)-(+)-pipecolic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 35677-83-9 (+)-2R-Piperidine-2-carboxylic acid methyl ester 
• 18650-38-9 (R)-piperidine-2-carboxylic acid methyl ester hydrochloride 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 186581-53-3 diazomethane 
• 28697-17-8 N-BOC-D-pipecolic acid 
• 1013212-42-4 tert-butyl 1-(R)-2-((S)-1,2-dihydroxylethyl)piperidine-1-carboxylate 
• 75844-69-8 t-butyl piperidinecarboxylate 
• 79-22-1 methyl chloroformate 
• 123387-55-3 1-t-butoxycarbonyl-2-tributylstannylpiperidine 
• 98303-20-9 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 768-33-2 phenyldimethylsilyl chloride 

Downstream Products

• 28697-17-8 N-BOC-D-pipecolic acid 
• 134441-61-5 tert-butyl (2R)-2-(hydroxymethyl)piperidine-1-carboxylate 
• 134526-69-5 tert-butoxycarbonyl-D-piperidine-2-carboxaldehyde 

Relevant articles and documents

Catalytic asymmetric hydrogenation of 1-aza-2-cycloalkene-2-carboxylates catalyzed by a trans-chelating chiral diphosphine PhTRAP-rhodium complex

A rhodium complex coordinated with a trans-chelating chiral diphosphine (S,S)-(R,R)-PhTRAP was an effective catalyst for asymmetric hydrogenation of N-acyl-1-aza-2-cycloalkene-2-carboxylates, which gave the corresponding protected cyclic α-amino acids wit

Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs

(-)-Cryptopleurine 1 is one of the most potent anti-proliferative member of the phenanthroquinolizidine class of alkaloids. We report here the synthesis of (-)-6-O-desmethylcryptopleurine (-)-2 and (-)-6-O-desmethyl-(15R)-hydroxycryptopleurine (-)-4 in th

Organocatalytic one-pot oxidative cleavage of terminal diols to dehomologated carboxylic acids

The organocatalytic one-pot oxidative cleavage of terminal 1,2-diols to one-carbon-unit-shorter carboxylic acids is described. The combination of 1-Me-AZADO (cat.), NaOCl (cat.), and NaClO2 caused smooth one-pot oxidative cleavage under mild conditions. A broad range of substrates including carbohydrates and N-protected amino diols were converted without epimerization. Terminal triols and tetraols respectively underwent cleavage of their C-2 and C-3 moieties to afford their corresponding two- and three-carbon-unit-shorter carboxylic acids.