164515-55-3

Basic information

• Product Name: C₄₈H₄₅Cl₂N₅O₁₆
• Synonyms: C₄₈H₄₅Cl₂N₅O₁₆
• CAS NO: 164515-55-3
• Molecular Weight: 1018.82
• Mol File: 164515-55-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₈H₄₅Cl₂N₅O₁₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₈H₄₅Cl₂N₅O₁₆(164515-55-3)
• EPA Substance Registry System: C₄₈H₄₅Cl₂N₅O₁₆(164515-55-3)

Safety Data

• Hazardous Substances Data: 164515-55-3(Hazardous Substances Data)

Upstream product

• 145007-42-7 C₄₃H₃₇Cl₂N₅O₁₄ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 164515-65-5 C₅₃H₅₃Cl₂N₅O₁₈ 

Downstream Products

• 164515-56-4 C₅₆H₅₁Cl₂N₅O₁₈ 

Relevant articles and documents

Structural modifications of the active site in teicoplanin and related glycopeptides. 2. Deglucoteicoplanin-derived tetrapeptide

The deglucoteicoplanin-derived tetrapeptide (TDTP), a key synthon suitable for the synthesis of modified glycopeptide antibiotics differing in the structure of the active site, was prepared from the product (RH-TD) of reductive hydrolysis of the 2,3-peptide bond of deglucoteicoplanin (TD) upon selective oxidation of the newly formed hydroxymethyl group and following simultaneous removal of amino acids 1 and 3 by double Edman degradation. The oxidation of the alcohol function of residue 2 in RH-TD was accomplished (Jones reagent) after protection of the two free amino groups as tert-butyl BOC carbamates and of most of phenolic hydroxy groups as benzyl CBZ carbonates. Esterification of the C-terminal carboxy group of intermediate di-BOC-RH-TD allowed the formation at the end of the process of the tetrapeptide (TDTP-Me) protected at one carboxy group as methyl ester. Selective protection of the primary N4- and N2-amino groups of TDTP-Me as BOC and CBZ carbamates, respectively, followed by removal of the BOC function, afforded a more suitable intermediate (N2-CBZ-TDTP-Me) for the synthesis of new glycopeptides.