164526-15-2Relevant academic research and scientific papers
A new effective route for the synthesis of substituted 2H-indazoles
Mochalov,Khasanov,Trofimova,Fedotov,Zefirov
experimental part, p. 1208 - 1217 (2010/06/12)
A two-stage synthesis of 2H-indazoles has been established, based on consecutive reactions of reduction of 2-alkyl-, 2-cyclopropyl-, and 2-arylcarbonylazobenzenes to phenylazo-substituted benzyl alcohols and intramolecular heterocyclization of the reducti
Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction
Butin, Alexander V.,Smirnov, Sergey K.,Stroganova, Tatyana A.,Bender, Wolfgang,Krapivin, Gennady D.
, p. 474 - 491 (2007/10/03)
A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus.
Substituted quinazolines and analogs and use thereof
-
, (2008/06/13)
The invention relates to novel quinazolines and heterocycles which are antagonists or positive modulators of AMPA receptors, and the use thereof for treating, preventing or ameliorating neuronal loss associated with stroke, global and focal ischemia, CNS trauma, hypoglycemia and surgery, as well as treating or ameliorating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Down's syndrome, treating, preventing or ameliorating the adverse consequences of the overstimulation of the excitatory amino acids, treating, preventing or ameliorating anxiety, psychosis, convulsions, chronic pain, glaucoma, retinitis, urinary incontinence, muscular spasm and inducing anesthesia, as well as for treating or ameliorating the adverse consequences of excitatory amino acid deficiency such as schizophrenia, myoclonus. Alzheimer's disease and malnutrition and neural maldevelopment, and as cognition and learning enhancers.
SYNTHESIS OF 1,3-DIHYDRO-5(R)-7,8-ETHYLENEDIOXY-2H-1,4-BENZO-DIAZEPIN-2-ONES
Mochalov, S. S.,Kosynkin, D. V.,Yudin, I. D.,Atanov, V. N.,Shabarov, Yu. S.,Zefirov, N. S.
, p. 527 - 532 (2007/10/02)
1-Diazepin-2-ones have been prepared from 1,4-benzodioxane for the first time.
