16458-73-4Relevant academic research and scientific papers
Copper-Catalyzed Inter- and Intramolecular C-N Bond Formation: Synthesis of Benzimidazole-Fused Heterocycles
Rasheed, Sk.,Rao, D. Nageswar,Das, Parthasarathi
, p. 9321 - 9327 (2015)
A Cu (II)-catalyzed, inter/intramolecular C-N bond formation for the synthesis of various benzimidazole-fused heterocycles in a concise manner has been reported. The robustness of this reaction is demonstrated by the synthesis of a series of benzimidazole-fused heteroaromatics (e.g., pyrido[1,2-a] benzimidazole, benzimidazo[1,2-a]quinolines, benzimidazo [1,2-a]pyrazine, benzo[4,5] imidazo[2,1-b]thiazoles) directly from 2-aminoheteroarenens and 2-iodoarylboronic acids in one-pot. The novel cascade protocol for C-N bond formation operates via unique combination of Chan-Lam type coupling followed by Ullmann-type reaction.
Synthesis method of thiazolo [3,2-a] benzimidazole compound and its application
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Paragraph 0045-0047, (2022/01/08)
The present invention provides a synthesis method of thiazolo [3,2-a] benzimidazole compounds, the synthesis method of alkyne does not require pre-functionalization, the synthesis steps are simple; the reaction conditions are mild, can be reacted at room
One-Pot Synthesis of Benzimidazo[2,1-b]thiazoline Derivatives through an Addition/Cyclization/Oxidative Coupling Reaction
Wang, Haofeng,Wu, Xin,Wang, Luyu,Li, Erfei,Li, Xiaoyu,Tong, Tao,Kang, Honglan,Xie, Jianwu,Shen, Guodong,Lv, Xin
, p. 11934 - 11941 (2020/10/23)
A novel and efficient approach to the synthesis of benzimidazo[2,1-b]thiazoline derivatives has been developed through an addition/cyclization/intramolecular oxidative C-H functionalization process. A variety of alkylene benzimidazo[2,1-b] thiazolines were conveniently assembled from the reaction of aryl isothiocyanate and propargylic amine in the presence of Cu(OAc)2 and PIFA at room temperature. The product could be further converted to substituted benzimidazo[2,1-b]thiazole derivatives.
